MabCent-SFI, University of Tromsø, Breivika N-9037 Tromsø, Norway.
Mar Drugs. 2013 Jul 22;11(7):2655-66. doi: 10.3390/md11072655.
In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1β and TNFα from LPS-stimulated THP-1 cells. This combination of anti-inflammatory and antioxidant activities could indicate that barettin has an atheroprotective effect and may therefore be an interesting product to prevent development of atherosclerosis.
本文从海洋海绵 Geodia barretti 中分离得到的巴瑞亭具有新的生物活性。我们发现巴瑞亭在生化分析和脂质过氧化细胞测定中均表现出较强的抗氧化活性。脱溴的巴瑞亭合成类似物在抗氧化细胞测定中没有表现出相同的活性，表明溴对细胞活性很重要。巴瑞亭还能够抑制 LPS 刺激的 THP-1 细胞中炎症细胞因子 IL-1β和 TNFα的分泌。这种抗炎和抗氧化活性的结合表明巴瑞亭具有抗动脉粥样硬化作用，因此可能是预防动脉粥样硬化发展的有趣产品。
