Malendowicz L K, Filipiak B
Endokrinologie. 1975 Jan;64(2):223-31.
Morphometrical and histochemical studies were performed to determine the effects of adrenalectomy and hydrocortisone replacement on the rat thyroid. It follows from the performed studies that morphometrical and histochemical changes in the rat thyroid induced by adrenalectomy or hydrocortisone replacement depend upon the duration of the experiment. From the 4th day of the experiment adrenalectomy results in an increase in the volume fraction of the epithelium of the thyroid vesicles with a concomitant decrease of the colloid fraction. As compared to sham operated animals on the 10th day of the experiment the increase in the height of the epithelial cells was seen. Hydrocortisone replacement partially prevents the thyroid changes induced by adrenalectomy, however, this hormone markedly increases the volume fraction of the thyroid stroma and the height of the epithelial cells. On the other hand, histochemical reactions for various oxido-reductases do not provide helpful information for evaluation of the secretory activity of the rat thyroid. It follows from our results that adrenalectomy enhances thyroid stimulation by TSH and enhances the secretory activity of this gland, effects partially prevented by hydrocortisone replacement.
进行了形态计量学和组织化学研究，以确定肾上腺切除术和氢化可的松替代对大鼠甲状腺的影响。从所进行的研究可以看出，肾上腺切除术或氢化可的松替代引起的大鼠甲状腺形态计量学和组织化学变化取决于实验持续时间。实验第4天起，肾上腺切除术导致甲状腺泡上皮的体积分数增加，同时胶体分数减少。与实验第10天假手术动物相比，可见上皮细胞高度增加。氢化可的松替代部分阻止了肾上腺切除术引起的甲状腺变化，然而，这种激素显著增加了甲状腺基质的体积分数和上皮细胞的高度。另一方面，各种氧化还原酶的组织化学反应对于评估大鼠甲状腺的分泌活性没有提供有用信息。从我们的结果可以看出，肾上腺切除术增强了促甲状腺激素（TSH）对甲状腺的刺激并增强了该腺体的分泌活性，氢化可的松替代可部分阻止这些作用。
