McClements David Julian
Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Ther Deliv. 2013 Jul;4(7):841-57. doi: 10.4155/tde.13.46.
Nanoemulsions have considerable potential for encapsulating, protecting and delivering lipophilic bioactive components via the oral route, such as pharmaceuticals (drugs) and nutraceuticals (food components with specific health benefits). These systems can be fabricated from generally recognized as safe ingredients using relatively simple processing operations, such as mixing and homogenization. Some of the potential advantages of nanoemulsions over conventional emulsions include higher bioaccessibility, higher physical stability and higher optical clarity. An overview of the current status of nanoemulsion fabrication, stability, properties and biological fate is given, with special emphasis on the suitability of nanoemulsions for the oral delivery of hydrophobic bioactive components, such as drugs and nutraceuticals.
纳米乳剂在通过口服途径包封、保护和递送亲脂性生物活性成分方面具有巨大潜力，这些成分包括药物和营养保健品（具有特定健康益处的食品成分）。这些体系可以使用相对简单的加工操作，如混合和均质化，由一般认为安全的成分制备而成。纳米乳剂相对于传统乳剂的一些潜在优势包括更高的生物可及性、更高的物理稳定性和更高的光学透明度。本文综述了纳米乳剂的制备、稳定性、性质和生物学命运的现状，特别强调了纳米乳剂用于口服递送疏水性生物活性成分（如药物和营养保健品）的适用性。
