亚胺酯与富烯的催化不对称外消旋[6+3]环加成反应。
Catalytic asymmetric exo-selective [6+3] cycloaddition of iminoesters with fulvenes.
机构信息
Max-Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, Dortmund 44227, Germany.
出版信息
Chem Commun (Camb). 2013 Sep 14;49(71):7800-2. doi: 10.1039/c3cc43824d.
PMID:23884088
Abstract
A novel exo-selective [6+3] cycloaddition approach for the highly enantioselective synthesis of polysubstituted piperidines was developed. The developed methodology was applied in a one-pot [6+3]-[4+2] dicycloaddition, allowing the construction of structurally and stereochemically rich polycyclic compounds from simple building blocks.
摘要
发展了一种新颖的外消旋选择性[6+3]环加成方法，用于高对映选择性合成多取代的哌啶。所开发的方法学被应用于一锅[6+3]-[4+2]二环加成中，能够从简单的构建块构建结构和立体化学丰富的多环化合物。
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