β-取代硝基烯与偶氮二羧酸酯的催化 MBH 反应。

Catalytic MBH reaction of β-substituted nitroalkenes with azodicarboxylates.

机构信息

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

出版信息

Org Biomol Chem. 2013 Sep 14;11(34):5722-6. doi: 10.1039/c3ob40804c.

DOI:10.1039/c3ob40804c

PMID:23884292

Abstract

An unprecedented N-heterocyclic carbene (NHC) catalyzed Morita-Baylis-Hillman (MBH) reaction of β-substituted nitroalkenes and azodicarboxylates has been developed. Both β-aryl and β-alkyl nitroalkenes worked well for the reaction using 5 mol% of NHC catalyst, giving the desired α-hydrazino-α,β-unsaturated nitroalkenes in good to excellent yields.

摘要

一种前所未有的 N-杂环卡宾（NHC）催化的 Morita-Baylis-Hillman（MBH）反应已经被开发出来，用于 β-取代的硝基烯烃和偶氮二羧酸酯的反应。使用 5 mol%的 NHC 催化剂，β-芳基和 β-烷基硝基烯烃都能很好地进行反应，得到了所需的α-氢氮杂基-α，β-不饱和硝基烯烃，产率良好至优秀。