银离子在中性 pH 下折叠 i 型发夹结构。

Silver cations fold i-motif at neutral pH.

机构信息

School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.

出版信息

Chem Commun (Camb). 2013 Sep 11;49(70):7696-8. doi: 10.1039/c3cc43495h.

Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used acidic conditions to fold the DNA. Herein we describe the use of silver cations to fold an i-motif forming DNA sequence at physiological pH. Subsequent DNA unfolding can be achieved by chelation with cysteine.

摘要

i-Motif DNA 结构以前曾被用于许多不同的纳米技术应用，但所有这些应用都使用酸性条件来折叠 DNA。在此，我们描述了使用银离子在生理 pH 值下折叠 i-Motif 形成的 DNA 序列。随后可以通过与半胱氨酸螯合来实现 DNA 解折叠。