Soler J, Bordes R, Murcia C, López J J, Guanyabens C, Pons C, Ortuño F, Prat J
Servicios de Hematología, de Anatomía Patológica, Hospital de la Santa Creu i Sant Pau, Barcelona.
Med Clin (Barc). 1990 May 19;94(19):725-9.
We describe the histopathology, immunophenotype and immunogenotype of 10 cases of peripheral T-cell lymphoma. The majority of patients showed disseminated disease at the time of diagnosis. From a histopathological view point the cases were classified into 5 types: T zone lymphoma (4 cases); Lennert lymphoma (2 cases); pleomorphic lymphoma, small all type (2 cases); pleomorphic lymphoma of medium-sized cell type (1 case); pleomorphic lymphoma of large cell type (1 case). In most of them the neoplastic cells demonstrated a mature T-cell phenotype: CD3+, CD4+, CD8-, CD43+, CD45RO+, CD45RA-, CD20- and surface immunoglobulins. All cases studied displayed gene rearrangements for the T-cell receptor beta chain while the immunoglobulins genes remained in germinal configuration. Antibodies against the human T-cell lymphotropic virus type I were not found in the 9 samples studied.
我们描述了10例外周T细胞淋巴瘤的组织病理学、免疫表型和免疫基因型。大多数患者在诊断时表现为播散性疾病。从组织病理学角度来看，这些病例分为5种类型：T区淋巴瘤（4例）； Lennert淋巴瘤（2例）；多形性淋巴瘤，小细胞型（2例）；多形性淋巴瘤，中细胞型（1例）；多形性淋巴瘤，大细胞型（1例）。大多数病例中，肿瘤细胞表现出成熟T细胞表型：CD3 +、CD4 +、CD8 -、CD43 +、CD45RO +、CD45RA -、CD20 -和表面免疫球蛋白。所有研究病例均显示T细胞受体β链的基因重排，而免疫球蛋白基因保持胚系构型。在所研究的9个样本中未发现抗I型人类嗜T细胞病毒的抗体。
