Thibaut Aurore, Chatelle Camille, Ziegler Erik, Bruno Marie-Aurélie, Laureys Steven, Gosseries Olivia
Coma Science Group, Cyclotron Research Centre, University and University Hospital of Liège, Liège, Belgium.
Brain Inj. 2013;27(10):1093-105. doi: 10.3109/02699052.2013.804202. Epub 2013 Jul 25.
Spasticity following a stroke occurs in about 30% of patients. The mechanisms underlying this disorder, however, are not well understood.
This review aims to define spasticity, describe hypotheses explaining its development after a stroke, give an overview of related neuroimaging studies as well as a description of the most common scales used to quantify the degree of spasticity and finally explore which treatments are currently being used to treat this disorder.
The lack of consensus is highlighted on the basis of spasticity and the associated absence of guidelines for treatment, use of drugs and rehabilitation programmes.
Future studies require controlled protocols to determine the efficiency of pharmacological and non-pharmacological treatments for spasticity. Neuroimaging may help predict the occurrence of spasticity and could provide insight into its neurological basis.
中风后约30%的患者会出现痉挛。然而,这种疾病的潜在机制尚未完全明确。
本综述旨在定义痉挛,描述解释中风后其发展的假说,概述相关神经影像学研究,并描述用于量化痉挛程度的最常用量表,最后探讨目前用于治疗这种疾病的方法。
基于痉挛以及缺乏治疗、药物使用和康复计划指南的情况,突出了缺乏共识的问题。
未来的研究需要采用对照方案来确定治疗痉挛的药物和非药物治疗方法的有效性。神经影像学可能有助于预测痉挛的发生,并能深入了解其神经学基础。