职业性接触氯化烃和石油溶剂与蕈样肉芽肿。
Occupational exposure to chlorinated and petroleum solvents and mycosis fungoides.
机构信息
Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Burjasot, Valencia, Spain.
出版信息
J Occup Environ Med. 2013 Aug;55(8):924-31. doi: 10.1097/JOM.0b013e3182941a1c.
OBJECTIVE
To evaluate the potential association between occupational exposure to chlorinated and petroleum solvents and mycosis fungoides (MF).
METHODS
A questionnaire on lifetime job history was administered to 100 patients diagnosed with MF and 2846 controls. Odds ratios (ORs) were calculated as the measure of the association between exposure to each specific solvent and MF.
RESULTS
In the total sample and in men, cases and controls did not differ in relation to exposure to any of the solvents studied. In women, an association with MF was seen for the highest level of estimated exposure to perchloroethylene (OR = 11.38; 95% confidence interval: 1.04 to 124.85) and for exposure less than the median to kerosene/fuel/gasoil (OR = 8.53; 95% confidence interval: 1.11 to 65.62).
CONCLUSIONS
These results do not provide conclusive evidence that exposure to solvents may increase risk of MF because they were not found in men.
目的
评估职业性接触氯化和石油溶剂与蕈样肉芽肿（MF）之间的潜在关联。
方法
对 100 名被诊断为 MF 的患者和 2846 名对照者进行了一份关于终生职业史的问卷。将比值比（OR）作为暴露于每种特定溶剂与 MF 之间关联的度量。
结果
在总样本和男性中，病例组和对照组在暴露于任何研究溶剂方面均无差异。在女性中，与 MF 相关的是估计的最高水平的接触过氯乙烯（OR=11.38；95%置信区间：1.04 至 124.85）和低于中位数的接触煤油/燃料/瓦斯油（OR=8.53；95%置信区间：1.11 至 65.62）。
结论
这些结果并没有提供确凿的证据表明接触溶剂可能会增加 MF 的风险，因为在男性中并未发现这种关联。
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