Gomaa Nahed I M, Metwally Lobna A, Nemr Nader, Younis Soha
Department of Microbiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Egypt J Immunol. 2013;20(1):23-8.
Hepatitis D virus (HDV) is a defective RNA virus that needs hepatitis B surface antigen (HBsAg) from HBV for transmission. HDV can lead to fulminant hepatitis and the progression of chronic liver damage in patients with chronic hepatitis B. The aim of this study was to determine the seroprevalence of HDV among HBsAg positive individuals in Ismailia, Egypt. Serum samples were collected from 170 HBsAg positive healthy individuals from Suez Canal University blood bank over a one year period. All of them were seeking blood donation and found to be HBsAg positive during viral hepatitis screening workups which is routinely done prior to donation. Serum samples were screened for IgG antibodies to hepatitis delta virus (HDV) using enzyme-linked immunosorbent assay (ELISA) method. Anti-HDV antibodies were detected in 8 (4.7%) individuals aged from 29-43 years. Liver function tests showed that serum ALT and AST levels were elevated in the HBsAglanti-HDV positive cases. It is concluded that the rate of HDV infection in Ismailia is high and further investigation is needed to validate the findings and raise awareness about the risk of dual HBV and HDV infection.
丁型肝炎病毒（HDV）是一种缺陷RNA病毒，其传播需要乙型肝炎病毒（HBV）的乙型肝炎表面抗原（HBsAg）。HDV可导致暴发性肝炎，并使慢性乙型肝炎患者的慢性肝损伤病情进展。本研究的目的是确定埃及伊斯梅利亚HBsAg阳性个体中HDV的血清流行率。在一年时间里，从苏伊士运河大学血库采集了170名HBsAg阳性健康个体的血清样本。他们均为献血者，在献血前常规进行的病毒性肝炎筛查检查中被发现HBsAg呈阳性。采用酶联免疫吸附测定（ELISA）法对血清样本进行丁型肝炎病毒（HDV）IgG抗体筛查。在8名年龄为29至43岁的个体（4.7%）中检测到抗HDV抗体。肝功能检查显示，HBsAg/抗HDV阳性病例的血清ALT和AST水平升高。得出结论，伊斯梅利亚的HDV感染率较高，需要进一步调查以验证研究结果，并提高对HBV和HDV双重感染风险的认识。
