Alajab Mohamed Bushra, Ibn Auf Bushra, Rafei Ahmed, Abdo Abdelmoneim Eltayeib
University of Gezira, Wadmadani.
University of Khartoum.
Ann Med Surg (Lond). 2024 Jul 5;86(9):5091-5095. doi: 10.1097/MS9.0000000000002337. eCollection 2024 Sep.
Sudan has a high prevalence of hepatitis B surface antigen, exceeding 8%. The prevalence of hepatitis B varies across different regions of Sudan, ranging from 6.8% in central Sudan to as high as 26% in southern Sudan. Hepatitis D virus (HDV) relies on HBV for replication and can accelerate the progression of HBV-related liver diseases, leading to more severe outcomes. This study aims to determine the prevalence of HDV infection among Sudanese patients with HBV-related liver diseases and to investigate the clinical characteristics of patients with HDV co-infection.
DESIGN/METHOD: This descriptive cross-sectional hospital-based study was conducted in Sudan between June and September 2022. Ninety HBV patients aged 16 years and above were included. Patients were interviewed using a structured questionnaire, and medical histories and examinations were recorded. Investigations included liver function tests, abdominal ultrasounds, and ELISA for Anti-HDV IgG.
In this study of 90 HBV patients, most were male (68.9%) and under 40 years old (58.9%). HDV-IgG antibodies were found in 8 patients (8.9%), all male. Among the HDV-positive patients, one (12.5%) had jaundice and one (12.5%) had ascites. Elevated ALT levels were seen in 50% of HDV-positive patients. One (12.5%) HDV-positive patient had low albumin. Cirrhosis was present in 25% of HDV-positive patients, and HCC was present in 12.5% of HDV-positive patient.
The prevalence of HDV infection among Sudanese patients with HBV-related liver diseases is 8.9%. This highlights the need for enhanced screening and diagnostic measures in Sudanese populations. Further research is needed to develop targeted interventions.
苏丹乙肝表面抗原的流行率很高，超过8%。苏丹不同地区的乙肝流行率各不相同，从苏丹中部的6.8%到苏丹南部高达26%。丁型肝炎病毒（HDV）依赖乙肝病毒进行复制，可加速乙肝相关肝病的进展，导致更严重的后果。本研究旨在确定苏丹乙肝相关肝病患者中HDV感染的流行率，并调查HDV合并感染患者的临床特征。
设计/方法：这项基于医院的描述性横断面研究于2022年6月至9月在苏丹进行。纳入了90名16岁及以上的乙肝患者。使用结构化问卷对患者进行访谈，并记录病史和检查情况。调查包括肝功能检查、腹部超声以及抗HDV IgG的酶联免疫吸附测定。
在这项对90名乙肝患者的研究中，大多数为男性（68.9%）且年龄在40岁以下（58.9%）。在8名患者（8.9%）中发现了HDV-IgG抗体，均为男性。在HDV阳性患者中，1名（12.5%）有黄疸，1名（12.5%）有腹水。50%的HDV阳性患者谷丙转氨酶水平升高。1名（12.5%）HDV阳性患者白蛋白水平低。25%的HDV阳性患者有肝硬化，12.5%的HDV阳性患者有肝癌。
苏丹乙肝相关肝病患者中HDV感染的流行率为8.9%。这凸显了苏丹人群加强筛查和诊断措施的必要性。需要进一步研究以制定针对性的干预措施。
