铱(III)催化的肟和重氮化合物合成多取代异喹啉和吡啶 N-氧化物。
Rh(III)-catalyzed synthesis of multisubstituted isoquinoline and pyridine N-oxides from oximes and diazo compounds.
机构信息
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
出版信息
J Am Chem Soc. 2013 Aug 21;135(33):12204-7. doi: 10.1021/ja406338r. Epub 2013 Aug 9.
PMID:23889167
Abstract
Multisubstituted isoquinoline and pyridine N-oxides have been prepared by Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C-H activation. This intermolecular annulation involving tandem C-H activation, cyclization, and condensation steps proceeds under mild conditions, obviates the need for oxidants, releases N2 and H2O as the byproducts, and displays a broad substituent scope.
摘要
通过 Rh(III)催化肟和重氮化合物的芳基和乙烯基 C-H 活化，制备了多取代的异喹啉和吡啶 N-氧化物。这种涉及串联 C-H 活化、环化和缩合步骤的分子间环化反应在温和条件下进行，避免了氧化剂的需要，释放出 N2 和 H2O 作为副产物，并具有广泛的取代基范围。
Zotero 插件