铑催化的联芳基吡啶衍生物与内炔的直接偶联反应。

Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes.

作者信息

Zheng Jun, You Shu-Li

机构信息

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

出版信息

Chem Commun (Camb). 2014 Aug 4;50(60):8204-7. doi: 10.1039/c4cc02822h.

DOI:10.1039/c4cc02822h

PMID:24931462

Abstract

Axially chiral biaryls were synthesized by an isoquinoline or 2-pyridine-directed Rh(III)-catalyzed dual C-H cleavage and coupling with internal alkynes in good to excellent yields. Oxidation of isoquinoline derivatives with m-CPBA furnished their corresponding N-oxides, which could be utilized as Lewis base catalysts in asymmetric reactions.

摘要

通过异喹啉或2-吡啶导向的铑(III)催化的双C-H裂解反应以及与内炔烃的偶联反应，以良好至优异的产率合成了轴手性联芳基化合物。用间氯过氧苯甲酸氧化异喹啉衍生物可得到相应的N-氧化物，其可在不对称反应中用作路易斯碱催化剂。