Tan S, Kirk R C, Abraham W C, McNaughton N
Department of Psychology, University of Otago, Dunedin, New Zealand.
Psychopharmacology (Berl). 1990;101(4):550-4. doi: 10.1007/BF02244236.
Benzodiazepine and anticholinergic drugs interfere with septo-hippocampal function in similar but not identical ways. They also share a number of common behavioural effects and, in particular, both classes of drug interfere with spatial memory in the Morris Water Maze--a test which is very sensitive to hippocampal dysfunction. We have previously shown that the anticholinergic drug scopolamine impairs discriminability, but not rate of forgetting, in delayed conditional discrimination. In the present study forgetting was quantified by fitting a negative exponential function to estimates of discriminability derived from a signal detection analysis of data from an auditory delayed conditional discrimination task. Chlordiazepoxide produced a highly significant decrease in discriminability which was monotonically related to the logarithm of dose in the range 0.67-18.0 mg/kg IP. The rate of forgetting was not increased. These data confirm the pharmacological independence of changes in discriminability and rate of forgetting; demonstrate that in this task chlordiazepoxide has similar effects to scopolamine; and suggest that the effects of chlordiazepoxide in other working memory tasks could be more a result of changed stimulus processing than impairment of memorial processes.
苯二氮䓬类药物和抗胆碱能药物以相似但不完全相同的方式干扰隔-海马功能。它们还具有一些共同的行为效应，特别是这两类药物都会干扰莫里斯水迷宫中的空间记忆，莫里斯水迷宫是一种对海马功能障碍非常敏感的测试。我们之前已经表明，抗胆碱能药物东莨菪碱会损害延迟条件辨别中的辨别力，但不会影响遗忘率。在本研究中，通过对听觉延迟条件辨别任务数据进行信号检测分析得出的辨别力估计值拟合负指数函数来量化遗忘。氯氮䓬在0.67-18.0mg/kg腹腔注射剂量范围内，导致辨别力显著下降，且与剂量对数呈单调关系。遗忘率并未增加。这些数据证实了辨别力变化和遗忘率在药理学上的独立性；表明在这项任务中氯氮䓬与东莨菪碱有相似的作用；并表明氯氮䓬在其他工作记忆任务中的作用可能更多是由于刺激处理的改变，而非记忆过程的损害。
