Department of Vitreoretinal Diseases, St. Erik Eye Hospital and Karolinska Institutet, Stockholm, Sweden.
Acta Ophthalmol. 2014 Feb;92(1):21-6. doi: 10.1111/aos.12185. Epub 2013 Jul 26.
Geographic atrophy is a common and untreatable form of advanced age-related macular degeneration. The degeneration primarily affects the retinal pigment epithelium and photoreceptors of the retina and their restoration by cell transplantation seems attractive. Recently, a patient with geographic atrophy was the first human to receive cells derived from human embryonic stem cells. In this short review, the rationale, potential and obstacles for stem cell-derived therapy in geographic atrophy are discussed.
地理萎缩是一种常见且无法治愈的与年龄相关的黄斑退行性疾病。这种退行性病变主要影响视网膜的视网膜色素上皮和光感受器，通过细胞移植来恢复它们似乎很有吸引力。最近，一名地理萎缩患者成为首位接受源自人类胚胎干细胞的细胞治疗的人类。在这篇简短的综述中，讨论了干细胞衍生疗法治疗地理萎缩的原理、潜力和障碍。
