Cellular Reprogramming Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain.
Stem Cells. 2010 Jan;28(1):93-9. doi: 10.1002/stem.253.
Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber tracts that carry sensation and motor signals to and from the brain. The gray matter damage causes segmental losses of interneurons and motoneurons and restricts therapeutic options. Recent advances in stem cell biology, neural injury, and repair, and the progress toward development of neuroprotective and regenerative interventions are the basis for increased optimism. This review summarizes the pathophysiological mechanisms following SCI and compares human embryonic, adult neural, and the induced pluripotent stem cell-based therapeutic strategies for SCI.
脊髓损伤 (SCI) 导致脊髓病变、白质损伤和有髓纤维束损伤，这些损伤会将感觉和运动信号传递到大脑和从大脑传出。灰质损伤导致中间神经元和运动神经元的节段性丧失，并限制了治疗选择。干细胞生物学、神经损伤和修复方面的最新进展，以及神经保护和再生干预措施的发展进展，是增加乐观情绪的基础。本文综述了 SCI 后的病理生理机制，并比较了人胚胎、成人神经和基于诱导多能干细胞的 SCI 治疗策略。
