双生子分析在 I 型双相情感障碍中的冲动性研究。
A sib-pair analysis of impulsivity in bipolar disorder type I.
机构信息
Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
出版信息
Compr Psychiatry. 2013 Nov;54(8):1148-52. doi: 10.1016/j.comppsych.2013.05.019. Epub 2013 Jul 25.
OBJECTIVE
The aim of this study was to compare impulsivity among patients with bipolar disorder, their siblings, and healthy controls in order to examine whether impulsivity in bipolar disorder is related to genetic liability for the illness.
METHODS
Using the Barratt Impulsiveness Scale, we assessed 204 subjects: 67 euthymic outpatients with bipolar disorder type I, 67 siblings without bipolar disorder, and 70 healthy controls.
RESULTS
Impulsivity scores were higher among patients with bipolar disorder than among healthy controls. Siblings showed higher motor impulsivity scores than did healthy controls.
CONCLUSIONS
Our results suggest that motor impulsivity may be a vulnerability marker for bipolar disorder. Our data may contribute to further improve preventive strategies in subjects at high risk for bipolar disorder.
目的
本研究旨在比较双相障碍患者、其兄弟姐妹和健康对照组之间的冲动性，以检验双相障碍中的冲动性是否与该病的遗传易感性有关。
方法
使用巴瑞特冲动量表，我们评估了 204 名受试者：67 名心境稳定的 I 型双相障碍门诊患者、67 名无双相障碍的兄弟姐妹和 70 名健康对照者。
结果
双相障碍患者的冲动性评分高于健康对照组。与健康对照组相比，双相障碍患者的兄弟姐妹表现出更高的运动冲动性评分。
结论
我们的研究结果表明，运动冲动性可能是双相障碍的易感性标志物。我们的数据可能有助于进一步改善对双相障碍高危人群的预防策略。
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