Service d'ORL et de chirurgie cervico-faciale, formation associée Claude-Bernard, CNRS UMR 8194, université Paris Descartes et Sorbonne Cité Paris, HEGP, 20, rue Leblanc, 75908 Paris cedex 15, France.
Eur Ann Otorhinolaryngol Head Neck Dis. 2013 Nov;130(5):289-91. doi: 10.1016/j.anorl.2012.11.004. Epub 2013 Jul 23.
Inverted papilloma (IP) is the most frequent benign tumor of the nasal cavities. Recurrence is found in 12 to 14% of cases, mainly at the primary site, although also exceptionally in remote locations. The present paper discusses the physiopathogenesis of IP on the basis of a report of late second occurrence of IP at a remote location and a review of the literature.
A man, who had undergone surgery in 1997 for ethmoid IP at the age of 56, presented 11 years later with nasal cavity IP at a second (frontal) location, discovered serendipitously during systematic follow-up and managed surgically without complication.
The physiopathology of nasal cavity IP remains unexplained. No reliable histologic or biological markers predict risk of recurrence or of malignant transformation. The sole treatment is total surgical resection. The risk of local recurrence, often due to incomplete resection, is well known, but that of a secondary location is less so, and regular very long-term follow-up is justified.
内翻性乳头状瘤（IP）是鼻腔最常见的良性肿瘤。12%到 14%的病例会出现复发，主要发生在原发病灶，但也偶发于远处部位。本文根据一份远处部位 IP 二次发生的病例报告，并复习文献，探讨了 IP 的病理生理学。
一名 56 岁男性曾于 1997 年因筛窦 IP 接受手术治疗，11 年后，在系统随访中偶然发现额窦 IP，再次接受手术治疗，无并发症。
鼻腔 IP 的病理生理学仍不清楚。没有可靠的组织学或生物学标志物可以预测复发风险或恶性转化风险。唯一的治疗方法是完全手术切除。局部复发的风险（通常是由于切除不完整）是众所周知的，但远处部位复发的风险较小，因此需要进行长期定期随访。
