Department of Internal Medicine, Puli Branch of Taichung Veterans General Hospital, Taichung, Taiwan.
Sleep Med. 2013 Sep;14(9):913-8. doi: 10.1016/j.sleep.2013.03.024. Epub 2013 Jul 25.
The evidence concerning the relationship between nonapnea sleep disorders and the risk for type 2 diabetes mellitus (DM) is scant and elusive. Our study aimed to examine if nonapnea sleep disorders increase the risk for DM using a population-based retrospective cohort study from 1997 to 2010.
In the Taiwan's National Health Insurance Research Database (NHIRD), 45,602 patients with nonapnea sleep disorders were identified as the study cohort. The comparison cohort was formed by 91,204 age- and gender-matched controls. Cox proportional hazards regression model was used to estimate the risk for developing DM.
In 45,602 patients with nonapnea sleep disorders, 7241 new cases of DM were reported during the follow-up period. The mean follow-up time was 9.04 (standard deviation [SD], 3.33) and 8.96 (SD, 3.47) for the nonapnea sleep disorders cohort and the comparison cohort, respectively. The incidence rate of DM was higher in the nonapnea sleep disorder cohort than in the comparison cohort (17.6 vs 13.3 per 1000 individuals-years). Overall, patients with nonapnea sleep disorders had a higher risk for DM compared to patients without nonapnea sleep disorders (adjusted hazard ratio [HR], 1.05 [95% confidence interval {CI}, 1.02-1.08]). Men with nonapnea sleep disorders had a higher risk for DM than the men in the comparison group (adjusted HR, 1.08 [95% CI, 1.03-1.14]). Among subjects aged less than 40years, patients with nonapnea sleep disorders had a higher risk for DM than the comparison group (adjusted HR, 1.42 [95% CI, 1.27-1.59]). Compared with the comparison cohort, patients with sleep disturbance had an 11% higher risk for DM (adjusted HR, 1.11 [95% CI, 1.07-1.16]).
Compared to patients without nonapnea sleep disorders, patients with nonapnea sleep disorders had a higher risk for developing DM, especially among those who were less than 40years of age and who had sleep disturbances.
非呼吸睡眠障碍与 2 型糖尿病（DM）风险之间的关系证据很少且难以捉摸。我们的研究旨在使用 1997 年至 2010 年的基于人群的回顾性队列研究，检查非呼吸睡眠障碍是否会增加 DM 的风险。
在台湾全民健康保险研究数据库（NHIRD）中，确定了 45602 名非呼吸睡眠障碍患者作为研究队列。对照组由 91204 名年龄和性别匹配的对照组成。使用 Cox 比例风险回归模型估计发生 DM 的风险。
在 45602 名非呼吸睡眠障碍患者中，随访期间报告了 7241 例新的 DM 病例。非呼吸睡眠障碍队列和对照组的平均随访时间分别为 9.04（标准差 [SD]，3.33）和 8.96（SD，3.47）。非呼吸睡眠障碍组的 DM 发生率高于对照组（17.6 比 13.3 每 1000 人年）。总体而言，与没有非呼吸睡眠障碍的患者相比，患有非呼吸睡眠障碍的患者发生 DM 的风险更高（调整后的风险比 [HR]，1.05 [95%置信区间 {CI}，1.02-1.08]）。患有非呼吸睡眠障碍的男性比对照组中的男性发生 DM 的风险更高（调整后的 HR，1.08 [95%CI，1.03-1.14]）。在年龄小于 40 岁的人群中，与对照组相比，患有非呼吸睡眠障碍的患者发生 DM 的风险更高（调整后的 HR，1.42 [95%CI，1.27-1.59]）。与对照组相比，患有睡眠障碍的患者发生 DM 的风险增加了 11%（调整后的 HR，1.11 [95%CI，1.07-1.16]）。
与没有非呼吸睡眠障碍的患者相比，患有非呼吸睡眠障碍的患者发生 DM 的风险更高，尤其是在年龄小于 40 岁且存在睡眠障碍的患者中。
