Pulmonary Department-Oncology Unit, G. Papanikolaou General Hospital, Aristotle Univesrity of Thessaloniki, Thessaloniki, Greece.
Int J Pharm. 2013 Oct 15;455(1-2):182-8. doi: 10.1016/j.ijpharm.2013.07.040. Epub 2013 Jul 23.
Several aerosol antibiotics are on the market and several others are currently being evaluated. Aim of the study was to evaluate the aerosol droplet size of five different antibiotics for future evaluation as an aerosol administration.
The nebulizers Sunmist(®), Maxineb(®) and Invacare(®) were used in combination with four different "small <6 ml" residual cups and two "large <10 ml" with different loadings 2-4-6-8 ml (8 ml only for large residual cups) with five different antibiotic drugs (ampicilln-sulbactam, meropenem, ceftazidime, cefepime and piperacillin-tazobactam). The Mastersizer 2000 (Malvern) was used to evaluate the produced droplet size from each combination
Significant effect on the droplet size produced the different antibiotic (F=96.657, p<0.001) and the residual cup design (F=68.535, p<0.001) but not the different loading amount (p=0.127) and the nebulizer (p=0.715). Interactions effects were found significant only between antibiotic and residual cup (F=16.736, p<0.001). No second order interactions were found statistically significant.
Our results firstly indicate us indirectly that the chemical formulation of the drug is the main factor affecting the produced droplet size and secondly but closely the residual cup design.
市面上有几种雾化抗生素，还有几种正在评估中。本研究的目的是评估五种不同抗生素的雾化液滴大小，以便将来作为雾化给药进行评估。
使用 Sunmist(®)、Maxineb(®)和 Invacare(®)雾化器，与四个不同的“小 <6ml”残留杯和两个“大 <10ml”残留杯（仅大残留杯有 8ml 装量）结合，分别加载 2-4-6-8ml（仅大残留杯有 8ml 装量）的五种不同抗生素药物（氨苄西林-舒巴坦、美罗培南、头孢他啶、头孢吡肟和哌拉西林-他唑巴坦）。使用 Mastersizer 2000（马尔文）评估每种组合产生的液滴大小。
不同抗生素（F=96.657，p<0.001）和残留杯设计（F=68.535，p<0.001）对产生的液滴大小有显著影响，但不同加载量（p=0.127）和雾化器（p=0.715）没有影响。仅在抗生素和残留杯之间发现了相互作用效应有统计学意义（F=16.736，p<0.001）。没有发现统计学上显著的二阶相互作用。
我们的结果首先间接地表明药物的化学配方是影响产生的液滴大小的主要因素，其次但密切相关的是残留杯设计。
