左氧氟沙星单独及与阿奇霉素、头孢他啶、黏菌素（多黏菌素E）、美罗培南、哌拉西林-他唑巴坦和妥布霉素联合应用对铜绿假单胞菌的突变预防浓度。
Mutant prevention concentrations of levofloxacin alone and in combination with azithromycin, ceftazidime, colistin (Polymyxin E), meropenem, piperacillin-tazobactam, and tobramycin against Pseudomonas aeruginosa.
作者信息
Zhanel George G, Mayer Matthew, Laing Nancy, Adam Heather J
机构信息
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
出版信息
Antimicrob Agents Chemother. 2006 Jun;50(6):2228-30. doi: 10.1128/AAC.01620-05.
Abstract
The mutant prevention concentrations (MPCs) of levofloxacin alone and in combination with ceftazidime, colistin (polymyxin E), meropenem, piperacillin-tazobactam, and tobramycin were established against Pseudomonas aeruginosa. Antibiotic combinations using levofloxacin with any antibiotic with individual activity against P. aeruginosa resulted in synergistic lowering (an at-least-fourfold reduction) of the isolate's MPC.
摘要
测定了左氧氟沙星单独使用以及与头孢他啶、黏菌素（多黏菌素E）、美罗培南、哌拉西林-他唑巴坦和妥布霉素联合使用时对铜绿假单胞菌的突变预防浓度（MPC）。左氧氟沙星与任何对铜绿假单胞菌具有单独活性的抗生素联合使用，均导致分离株的MPC协同降低（至少降低四倍）。
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Int J Antimicrob Agents. 2005 Nov;26(5):380-8. doi: 10.1016/j.ijantimicag.2005.08.003.
2
A review of Streptococcus pneumoniae infection treatment failures associated with fluoroquinolone resistance.与氟喹诺酮耐药相关的肺炎链球菌感染治疗失败的综述。
Clin Infect Dis. 2005 Jul 1;41(1):118-21. doi: 10.1086/430829. Epub 2005 May 26.
3
Quinolones in 2005: an update.2005年喹诺酮类药物：最新进展
Clin Microbiol Infect. 2005 Apr;11(4):256-80. doi: 10.1111/j.1469-0691.2005.01131.x.
4
Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates.野生型、外排阳性或含有ParC或GyrA突变的肺炎链球菌分离株的单步氟喹诺酮耐药突变体的突变预防浓度。
Antimicrob Agents Chemother. 2004 Oct;48(10):3954-8. doi: 10.1128/AAC.48.10.3954-3958.2004.
5
Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis.联合抗菌治疗能否降低革兰氏阴性菌血症的死亡率？一项荟萃分析。
Lancet Infect Dis. 2004 Aug;4(8):519-27. doi: 10.1016/S1473-3099(04)01108-9.
6
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Int J Antimicrob Agents. 2004 May;23(5):451-6. doi: 10.1016/j.ijantimicag.2003.11.006.
7
The mutant selection window and antimicrobial resistance.突变选择窗与抗菌药物耐药性
J Antimicrob Chemother. 2003 Jul;52(1):11-7. doi: 10.1093/jac/dkg269. Epub 2003 Jun 12.
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