痒觉的神经处理。
Neural processing of itch.
机构信息
University of California, Davis, Department of Neurobiology, Physiology & Behavior, 1 Shields Avenue, Davis, CA 95616, United States.
出版信息
Neuroscience. 2013 Oct 10;250:697-714. doi: 10.1016/j.neuroscience.2013.07.035. Epub 2013 Jul 24.
Abstract
While considerable effort has been made to investigate the neural mechanisms of pain, much less effort has been devoted to itch, at least until recently. However, itch is now gaining increasing recognition as a widespread and costly medical and socioeconomic issue. This is accompanied by increasing interest in the underlying neural mechanisms of itch, which has become a vibrant and rapidly-advancing field of research. The goal of the present forefront review is to describe the recent progress that has been made in our understanding of itch mechanisms.
摘要
虽然人们已经投入了大量的精力来研究疼痛的神经机制，但至少直到最近，人们对瘙痒的研究还很少。然而，瘙痒现在正被越来越多地认为是一个广泛存在且代价高昂的医学和社会经济问题。这伴随着人们对瘙痒潜在神经机制的兴趣日益增加，该领域已成为一个充满活力和快速发展的研究领域。本前沿综述的目的是描述我们在理解瘙痒机制方面所取得的最新进展。
相似文献
1
Neural processing of itch.痒觉的神经处理。
Neuroscience. 2013 Oct 10;250:697-714. doi: 10.1016/j.neuroscience.2013.07.035. Epub 2013 Jul 24.
2
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.一种感觉神经元表达的白细胞介素-31 受体介导 T 辅助细胞依赖性瘙痒：涉及 TRPV1 和 TRPA1。
J Allergy Clin Immunol. 2014 Feb;133(2):448-60. doi: 10.1016/j.jaci.2013.10.048. Epub 2013 Dec 25.
3
Scratching inhibits serotonin-evoked responses of rat dorsal horn neurons in a site- and state-dependent manner.搔抓以部位和状态依赖的方式抑制大鼠背角神经元中 5-羟色胺诱发的反应。
Neuroscience. 2013 Oct 10;250:275-81. doi: 10.1016/j.neuroscience.2013.07.012. Epub 2013 Jul 15.
4
Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.中枢阿片受体通过去抑制介导吗啡诱导的瘙痒和慢性瘙痒。
Brain. 2021 Mar 3;144(2):665-681. doi: 10.1093/brain/awaa430.
5
Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors.P 物质和胃泌素释放肽作为初级传入瘙痒感受器释放的神经递质的作用。
J Neurophysiol. 2013 Feb;109(3):742-8. doi: 10.1152/jn.00539.2012. Epub 2012 Nov 14.
6
Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch.谷氨酸、P物质和胃泌素释放肽作为组胺能和非组胺能瘙痒的脊髓神经递质的作用。
Pain. 2014 Jan;155(1):80-92. doi: 10.1016/j.pain.2013.09.011. Epub 2013 Sep 13.
7
Facial injections of pruritogens or algogens elicit distinct behavior responses in rats and excite overlapping populations of primary sensory and trigeminal subnucleus caudalis neurons.面部注射致痒剂或致痛剂会在大鼠中引起不同的行为反应，并兴奋初级感觉和三叉神经尾核亚核的重叠神经元群。
J Neurophysiol. 2011 Sep;106(3):1078-88. doi: 10.1152/jn.00302.2011. Epub 2011 Jun 8.
8
B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway.B 型利钠肽既非瘙痒特异性递质，也不在 GRP-GRPR 信号通路的上游发挥作用。
Mol Pain. 2014 Jan 18;10:4. doi: 10.1186/1744-8069-10-4.
9
Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.B型利钠肽、胃泌素释放肽及其同源受体在调节小鼠瘙痒中的脊髓功能
J Pharmacol Exp Ther. 2016 Mar;356(3):596-603. doi: 10.1124/jpet.115.229997. Epub 2015 Dec 15.
10
Spinal cord interneurons expressing the gastrin-releasing peptide receptor convey itch through VGLUT2-mediated signaling.表达胃泌素释放肽受体的脊髓中间神经元通过VGLUT2介导的信号传导传递瘙痒。
Pain. 2017 May;158(5):945-961. doi: 10.1097/j.pain.0000000000000861.
引用本文的文献
1
Characterization and targeting of the endosomal signaling of the gastrin releasing peptide receptor in pruritus.瘙痒症中胃泌素释放肽受体的内体信号传导的表征与靶向作用
bioRxiv. 2025 Mar 17:2025.03.17.643743. doi: 10.1101/2025.03.17.643743.
2
Mechanisms of Itch in Atopic Dermatitis.特应性皮炎中的瘙痒机制
Juntendo Med J. 2025 Jan 30;71(1):43-50. doi: 10.14789/ejmj.JMJ24-0036-R. eCollection 2025.
3
An intra-brainstem circuitry for pain-induced inhibition of itch.一种用于疼痛诱导瘙痒抑制的脑桥内神经回路。
Neuroscience. 2025 Mar 5;568:95-107. doi: 10.1016/j.neuroscience.2025.01.008. Epub 2025 Jan 6.
4
Neuroimmune recognition of allergens.神经免疫识别过敏原。
Curr Opin Immunol. 2024 Oct;90:102458. doi: 10.1016/j.coi.2024.102458. Epub 2024 Aug 29.
5
Short-term Heat Application Reduces Itch Intensity in Atopic Dermatitis: Insights from Mechanical Induction and Real-life Episodes.短期热应用可降低特应性皮炎的瘙痒强度：机械诱导和现实发作的见解。
Acta Derm Venereol. 2024 Jun 17;104:adv40127. doi: 10.2340/actadv.v104.40127.
6
Genetic analyses unravel the causal association of cytokine levels on lichen simplex chronicus risk: insights from a mendelian randomization study.遗传分析揭示了细胞因子水平与慢性单纯性苔藓风险之间的因果关联：来自孟德尔随机研究的见解。
Arch Dermatol Res. 2024 May 25;316(6):241. doi: 10.1007/s00403-024-02964-8.
7
Effects of 0.15% ropivacaine alone and combination with sufentanil on epidural labor analgesia and adverse reactions.0.15%罗哌卡因单独应用及联合舒芬太尼对硬膜外分娩镇痛效果及不良反应的影响。
Afr Health Sci. 2023 Sep;23(3):569-575. doi: 10.4314/ahs.v23i3.66.
8
Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch.靶向瞬时受体电位（TRP）通道、Mas相关G蛋白偶联受体（Mrgprs）和蛋白酶激活受体（PARs）以缓解瘙痒。
Pharmaceuticals (Basel). 2023 Dec 8;16(12):1707. doi: 10.3390/ph16121707.
9
Kappa opioid agonists in the treatment of itch: just scratching the surface?κ阿片受体激动剂在瘙痒治疗中的应用：只是触及表面？
Itch (Phila). 2023 Oct-Dec;8(4). doi: 10.1097/itx.0000000000000072. Epub 2023 Dec 6.
10
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.金黄色葡萄球菌通过 V8 蛋白酶-PAR1 轴驱动瘙痒和搔抓诱导的皮肤损伤。
Cell. 2023 Nov 22;186(24):5375-5393.e25. doi: 10.1016/j.cell.2023.10.019.
本文引用的文献
1
Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch.马相关 G 蛋白偶联受体与猪毛菜碱诱导的瘙痒
J Invest Dermatol. 2018 Feb;138(2):461-464. doi: 10.1016/j.jid.2017.05.042. Epub 2017 Oct 4.
2
The cells and circuitry for itch responses in mice.小鼠瘙痒反应的细胞和回路。
Science. 2013 May 24;340(6135):968-71. doi: 10.1126/science.1233765.
3
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.活动依赖性沉默揭示了具有不同功能的痒觉产生感觉神经元。
Nat Neurosci. 2013 Jul;16(7):910-8. doi: 10.1038/nn.3404. Epub 2013 May 19.
4
Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.兴奋性背角浅层中间神经元在功能上具有异质性，是痛觉和痒觉完全表达行为所必需的。
Neuron. 2013 Apr 24;78(2):312-24. doi: 10.1016/j.neuron.2013.03.001.
5
Overexpression of the gastrin-releasing peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch.在患有慢性瘙痒的灵长类动物中，皮肤神经纤维中胃泌素释放肽及其脊髓中受体的过表达。
J Invest Dermatol. 2013 Oct;133(10):2489-2492. doi: 10.1038/jid.2013.166. Epub 2013 Apr 4.
6
Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.鞘内应用吗啡引起的瘙痒和镇痛：对三叉丘脑束神经元不同群体的对比作用。
J Neurosci. 2013 Apr 3;33(14):6093-101. doi: 10.1523/JNEUROSCI.0216-13.2013.
7
The TGR5 receptor mediates bile acid-induced itch and analgesia.TGR5 受体介导胆酸诱导的瘙痒和镇痛。
J Clin Invest. 2013 Apr;123(4):1513-30. doi: 10.1172/JCI64551. Epub 2013 Mar 25.
8
Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold.肽能 CGRPα 初级感觉神经元编码热和痒，并持续抑制对冷的敏感性。
Neuron. 2013 Apr 10;78(1):138-51. doi: 10.1016/j.neuron.2013.01.030. Epub 2013 Mar 21.
9
Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine.变应原氯喹对表达 TRPA1、TRPV1 和 TRPM8 通道的感觉神经元的兴奋和调制。
J Biol Chem. 2013 May 3;288(18):12818-27. doi: 10.1074/jbc.M113.450072. Epub 2013 Mar 18.
10
Incidence and determinants of chronic pruritus: a population-based cohort study.慢性瘙痒症的发病情况及其决定因素：一项基于人群的队列研究。
Acta Derm Venereol. 2013 Sep 4;93(5):532-7. doi: 10.2340/00015555-1572.
Zotero 插件