0.15%罗哌卡因单独应用及联合舒芬太尼对硬膜外分娩镇痛效果及不良反应的影响。
Effects of 0.15% ropivacaine alone and combination with sufentanil on epidural labor analgesia and adverse reactions.
机构信息
Department of Anesthesiology, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan Province, China.
出版信息
Afr Health Sci. 2023 Sep;23(3):569-575. doi: 10.4314/ahs.v23i3.66.
OBJECTIVE
The aim of this study was to compare the impacts of 0.15% ropivacaine alone and 0.15% ropivacaine combined with sufentanil on epidural labor analgesia.
METHODS
A total of 297 eligible primiparae were randomly divided into group A (n=149, 0.15% ropivacaine + sufentanil) and group B (n=148, 0.15% ropivacaine). Visual analogue scale (VAS) scores prior to analgesia and 20 min following epidural medication, the maximum VAS score during labor, dosage of analgesic drugs, modified Bromage score, satisfaction degree, labor duration, delivery mode, 1-min and 5-min Apgar scores of newborns, adverse reactions during analgesia, and fever during labor were recorded.
RESULTS
Group A and B had similar VAS scores 20 min following epidural medication and maximum score during labor (P>0.05), which significantly fell compared with those before labor analgesia (P<0.05). The occurrence rates of nausea and vomiting were of significant difference (P<0.05).
CONCLUSION
0.15% ropivacaine alone achieves a comparable epidural labor analgesia effect to that of 0.15% ropivacaine + 0.05 µg/mL sufentanil on primiparae.
目的
本研究旨在比较单独使用 0.15%罗哌卡因和 0.15%罗哌卡因联合舒芬太尼对硬膜外分娩镇痛的影响。
方法
共纳入 297 例符合条件的初产妇，随机分为 A 组（n=149，0.15%罗哌卡因+舒芬太尼）和 B 组（n=148，0.15%罗哌卡因）。记录镇痛前和硬膜外用药后 20min 的视觉模拟评分（VAS）、分娩时的最大 VAS 评分、镇痛药用量、改良 Bromage 评分、满意度、产程、分娩方式、新生儿 1min 和 5min Apgar 评分、镇痛期间不良反应以及发热情况。
结果
A 组和 B 组硬膜外用药后 20min 的 VAS 评分和分娩时的最大 VAS 评分相似（P>0.05），与分娩镇痛前相比明显下降（P<0.05）。恶心呕吐的发生率存在显著差异（P<0.05）。
结论
在初产妇中，0.15%罗哌卡因单独使用与 0.15%罗哌卡因+0.05μg/ml 舒芬太尼的硬膜外分娩镇痛效果相当。
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