EA 3450 DevAH - Development, Adaptation and Disadvantage, Cardiorespiratory regulations and motor control, Université de Lorraine, F-54505, France.
EA 3450 DevAH - Development, Adaptation and Disadvantage, Cardiorespiratory regulations and motor control, Université de Lorraine, F-54505, France.
Pulm Pharmacol Ther. 2014 Feb;27(1):96-101. doi: 10.1016/j.pupt.2013.07.005. Epub 2013 Jul 23.
The 'cough network' exhibits plasticity at the sensor and integration levels leading to modulation of the strength or pattern of the cough reflex. Little is known about the interactions between cough and human activities, especially during exercise. The present study was designed to determine whether exercise, mimicked by electrically induced muscle contractions, can modify the incidence and/or strength of cough following mechanical stimulation of the trachea in anesthetized rabbits. Thirteen anesthetized, tracheotomized rabbits were studied by a total of 311 tracheal stimulations: 196 at rest and 115 during exercise. During muscle contractions, the incidence of the cough reflex (CR) decreased and the expiration reflex (ER) increased (p < 0.0001). The sensitivity of the CR and ER both decreased during exercise compared to the sensitivity of the CR at rest (p < 0.02), while the strength of the expulsive response remained unchanged. These results indicate that adjustments occurring during muscle contractions likely downregulate tracheal defensive reflexes in anesthetized rabbits.
“咳嗽网络”在传感器和整合水平上表现出可塑性，导致咳嗽反射的强度或模式发生调制。关于咳嗽与人类活动之间的相互作用，尤其是在运动期间的相互作用，人们知之甚少。本研究旨在确定在麻醉兔中，通过电诱导的肌肉收缩模拟运动是否会改变机械刺激气管后咳嗽的发生率和/或强度。对 13 只麻醉、气管切开的兔子进行了总共 311 次气管刺激：196 次在休息时，115 次在运动时。在肌肉收缩期间，咳嗽反射 (CR) 的发生率降低，呼气反射 (ER) 增加 (p < 0.0001)。与休息时的 CR 相比，运动时 CR 和 ER 的敏感性均降低 (p < 0.02)，而呼气反应的强度保持不变。这些结果表明，在麻醉兔中，肌肉收缩时发生的调节可能下调了气管防御反射。
