The antiglycolytic action on dental plaque of amine chlorides.

The influence on the glycolytic activity of dental plaque of different amine-hydrochloride compounds 300, 315 and 356 (oleylamine) respectively at concentrations equimolar to their corresponding amine fluorides 297, 242 and 335 at 250 ppm F-concentrations and of hexetidine and sodium laurylsulfate was tested in an in vivo/in vitro combination. Hexetidine and sodium laurylsulfate were assessed at concentrations equimolar to compound 315. After having refrained from oral hygiene for three days four test subjects rinsed for 3 minutes with 10 ml H2O. Plaque was collected from interdental areas immediately after the control water rinse and 6 and 60 minutes after rinsing for 3 minutes with 10 ml of test solution. The plaque then was exposed in vitro to 10% glucose solution, and pH-decreases due to glycolysis were recorded for 30 minutes. Rinsing with amine chlorides resulted in strong inhibition of glycolytic activity 6 minutes as well as 1 hour after rinsing. Hexetidine and sodium laurylsulfate did not depress the fermentation of glucose.