Department of Surgery, State Hospital, Trabzon, Turkey.
Inflammation. 2013 Dec;36(6):1576-83. doi: 10.1007/s10753-013-9702-3.
This study aims to investigate the influence of clotrimazol (CLTZ) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. Rats were divided into five groups as sham + saline, sham + CLTZ, sham + polyethylene glycol, ANP + saline, and ANP + CLTZ. ANP in rats was induced by glycodeoxycholic acid. The extent of acinar cell injury, mortality, systemic cardiorespiratory variables, functional capillary density (FCD), renal/hepatic functions, and changes in some enzyme markers for pancreatic and lung tissue were investigated during ANP in rats. The use of CLTZ after the induction of ANP resulted in a significant decrease in the mortality rate, pancreatic necrosis, and serum activity of amylase, alanine aminotransferase, interleukin-6, lactate dehydrogenase in bronchoalveolar lavage fluid, serum concentration of urea, and tissue activity of myeloperoxidase, and malondialdehyde in the pancreas and lung and a significant increase in concentrations of calcium, blood pressure, urine output, pO2, and FCD. This study showed that CLTZ demonstrated beneficial effect on the course of ANP in rats. Therefore, it may be used in the treatment of acute pancreatitis.
本研究旨在探讨克霉唑（CLTZ）对甘氨脱氧胆酸诱导的大鼠急性坏死性胰腺炎（ANP）的影响。大鼠分为五组：假手术+生理盐水、假手术+CLTZ、假手术+聚乙二醇、ANP+生理盐水和 ANP+CLTZ。通过甘氨脱氧胆酸诱导大鼠的 ANP。在大鼠的 ANP 期间，研究了胰腺和肺组织中一些酶标志物的变化、胰腺和肺组织中白细胞髓过氧化物酶和丙二醛的活性、胰腺和肺组织的功能毛细血管密度（FCD）、肾功能和肝功能，以及死亡率、胰腺坏死、血清淀粉酶、丙氨酸氨基转移酶、白细胞介素-6、乳酸脱氢酶活性、血清尿素浓度、肺泡灌洗液中血清浓度的变化。在诱导 ANP 后使用 CLTZ 可显著降低死亡率、胰腺坏死以及血清淀粉酶、丙氨酸氨基转移酶、白细胞介素-6、乳酸脱氢酶活性、肺泡灌洗液中血清尿素浓度、胰腺和肺组织中髓过氧化物酶和丙二醛的活性，以及钙浓度、血压、尿量、pO2 和 FCD。本研究表明，CLTZ 对大鼠 ANP 的病程有有益的影响。因此，它可能用于治疗急性胰腺炎。
