阿拉伯也门共和国病毒性肝炎血清流行病学调查

A seroepidemiological survey of viral hepatitis in the Yemen Arab Republic.

作者信息

Scott D A, Burans J P, al-Ouzeib H D, Arunkumar B K, al-Fadeel M, Nigad Y R, al-Hadad A, Elyazeed R R, Hyams K C, Woody J N

机构信息

US Naval Medical Research Unit Number Three, Cairo, Egypt.

出版信息

Trans R Soc Trop Med Hyg. 1990 Mar-Apr;84(2):288-91. doi: 10.1016/0035-9203(90)90290-u.

DOI:10.1016/0035-9203(90)90290-u

PMID:2389323

Abstract

During February 1988 a seroepidemiological survey of hepatitis A, B and D was performed in the Yemen Arab Republic. 879 sera were collected from 4 different areas; Sanaa, Hajja, Hodeidah and Taiz. The prevalence of hepatitis B surface antigen (HBsAg) was 12.7% (112/879) and some marker of hepatitis B infection was found in 45.5% (399/879) of study subjects. Only 2 (1.8%) of the 112 HBsAg positives were positive for antibody to delta hepatitis, and 9.7% (9/93) were positive for hepatitis B e antigen (HBeAg). Univariate analysis showed age, sex, qat chewing, blood transfusion, surgery and a past history of jaundice to be associated with hepatitis B infection. Using multivariate logistic regression analysis only, age (odds ratios 1.37 for HBsAg carriers and 1.51 for seropositives), a past history of jaundice (odds ratio 1.42), and combined history of blood transfusion and surgery (odds ratio 2.76) were independent predictors of infection. Hepatitis B appears to be a major health concern in the Yemen Arab Republic.

摘要

1988年2月，在阿拉伯也门共和国开展了一项甲型、乙型和丁型肝炎血清流行病学调查。从萨那、哈杰、荷台达和塔伊兹4个不同地区采集了879份血清样本。乙型肝炎表面抗原（HBsAg）的流行率为12.7%（112/879），45.5%（399/879）的研究对象检测到乙型肝炎感染的某些标志物。在112例HBsAg阳性者中，仅2例（1.8%）丁型肝炎抗体呈阳性，9.7%（9/93）乙型肝炎e抗原（HBeAg）呈阳性。单因素分析显示，年龄、性别、嚼咔特、输血、手术以及既往黄疸病史与乙型肝炎感染有关。仅采用多因素logistic回归分析时，年龄（HBsAg携带者的比值比为1.37，血清学阳性者为1.51）、既往黄疸病史（比值比为1.42）以及输血和手术合并史（比值比为2.76）是感染的独立预测因素。在阿拉伯也门共和国，乙型肝炎似乎是一个主要的健康问题。