Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA.
NMR Biomed. 2013 Dec;26(12):1672-9. doi: 10.1002/nbm.3001. Epub 2013 Jul 25.
The reduced field-of-view (rFOV) turbo-spin-echo (TSE) technique, which effectively suppresses bowel movement artifacts, is developed for the purpose of chemical exchange saturation transfer (CEST) imaging of the intervertebral disc (IVD) in vivo. Attempts to quantify IVD CEST signals in a clinical setting require high reliability and accuracy, which is often compromised in the conventionally used technique. The proposed rFOV TSE CEST method demonstrated significantly superior reproducibility when compared with the conventional technique on healthy volunteers, implying it is a more reliable measurement. Phantom study revealed a linear relation between CEST signal and glycosaminoglycan (GAG) concentration. The feasibility of detecting IVD degeneration was demonstrated on a healthy volunteer, indicating that the proposed method is a promising tool to quantify disc degeneration.
针对活体椎间盘化学交换饱和传递（CEST）成像，开发了一种有效抑制肠道运动伪影的小视野（rFOV）涡轮自旋回波（TSE）技术。在临床环境中量化椎间盘 CEST 信号需要高可靠性和准确性，而传统技术往往无法满足这些要求。与传统技术相比，该方法在健康志愿者中显示出明显更高的可重复性，这表明它是一种更可靠的测量方法。体模研究表明 CEST 信号与糖胺聚糖（GAG）浓度之间存在线性关系。在健康志愿者中证明了检测椎间盘退变的可行性，表明该方法是量化椎间盘退变的一种有前途的工具。
