Centre for Cellular and Molecular Biology (Council for Scientific and Industrial Research), Hyderabad, India.
Proteomics Clin Appl. 2014 Feb;8(1-2):86-98. doi: 10.1002/prca.201200082. Epub 2013 Oct 31.
Endometriosis is a complex gynecological disease, characterized by the presence and growth of endometrial tissue outside the uterus, resulting in pelvic pain and infertility. It occurs in 10% of women in their reproductive age. The viable endometrial cells enter the peritoneal cavity by retrograde menstruation, implant, and cause lesions ectopically; depending on their ability to survive, attach, grow, and invade. These "normal" endometrial cells turn "endometriotic" apparently because of inherent abnormalities present in them. Information on these molecular abnormalities is now being sought through proteomic approaches. Recent proteome-based comparisons between the eutopic endometrium from normal women and patients with endometriosis have revealed several proteins (many of which are shown to have a role in several cancers), of which a few have been validated as potential players in the etiology of endometriosis. After an initial in-flow of information from these proteome studies of eutopic endometrium, focus now needs to be expanded to the changes in the various protein PTMs and their upstream effectors present in these tissues. Early diagnosis of endometriosis through noninvasive means is the need of the hour as well-which would require the use of the presently existing immunoassays, along with the advancing MS-based proteomics. In this review, we aim to discuss these future thrust areas of human endometriosis proteomics and also present the proteomic advances made so far in understanding the molecular basis of endometriosis.
子宫内膜异位症是一种复杂的妇科疾病，其特征是子宫内膜组织在子宫外存在和生长，导致盆腔疼痛和不孕。它发生在 10%的育龄妇女中。有活力的子宫内膜细胞通过逆行性月经进入腹腔，植入并导致异位病变；这取决于它们的生存、附着、生长和侵袭能力。这些“正常”的子宫内膜细胞显然因为它们内在的异常而变成“子宫内膜异位症”。目前正在通过蛋白质组学方法寻找这些分子异常的信息。最近对正常妇女和子宫内膜异位症患者的在位子宫内膜进行的基于蛋白质组的比较研究揭示了几种蛋白质（其中许多在几种癌症中起作用），其中一些已被验证为子宫内膜异位症病因的潜在参与者。在这些在位子宫内膜的蛋白质组研究的初始信息流之后，现在需要将重点扩展到这些组织中存在的各种蛋白质 PTM 及其上游效应物的变化。通过非侵入性手段早期诊断子宫内膜异位症是当下的需要，这需要使用现有的免疫测定法，以及基于 MS 的蛋白质组学的进步。在这篇综述中，我们旨在讨论人类子宫内膜异位症蛋白质组学的这些未来重点领域，并介绍迄今为止在理解子宫内膜异位症分子基础方面取得的蛋白质组学进展。
