Macromolecular Chemistry I, University of Bayreuth, 95440, Bayreuth, Germany.
Macromol Biosci. 2013 Oct;13(10):1396-403. doi: 10.1002/mabi.201300221. Epub 2013 Jul 25.
Gradients are a natural design principle in biological systems that are used to diminish stress concentration where materials of differing mechanical properties connect. An interesting example of a natural gradient material is byssus, which anchors mussels to rocks and other hard substrata. Building upon previous work with synthetic polymers and inspired by byssal threads, protein gradient films are cast using glycerine-plasticized gelatine and fibroin exhibiting a highly reproducible and smooth mechanical gradient, which encompasses a large range of modulus from 160 to 550 MPa. The reproducible production of biocompatible gradient films represents a first step towards medical applications.
梯度是生物系统中的一种自然设计原则，用于减少不同力学性能材料连接时的应力集中。贻贝的足丝就是梯度材料的一个有趣的例子，它可以将贻贝固定在岩石和其他硬基底上。在之前使用合成聚合物的工作基础上，并受贻贝足丝的启发，利用甘油增塑明胶和丝素制作了蛋白梯度薄膜，该薄膜具有高度重现性和平滑的机械梯度，其模量范围从 160 到 550 MPa 不等。可重复生产的生物相容性梯度薄膜是迈向医学应用的第一步。
