Shah Lipa, Yadav Sunita, Amiji Mansoor
Department of Pharmaceutical Sciences School of Pharmacy Northeastern University Boston, MA 02115.
Drug Deliv Transl Res. 2013 Aug 1;3(4):336-51. doi: 10.1007/s13346-013-0133-3.
The current therapeutic strategies are not efficient in treating disorders related to the central nervous system (CNS) and have only shown partial alleviation of symptoms, as opposed to, disease modifying effects. With change in population demographics, the incidence of CNS disorders, especially neurodegenerative diseases, is expected to rise dramatically. Current treatment regimens are associated with severe side-effects, especially given that most of these are chronic therapies and involve elderly population. In this review, we highlight the challenges and opportunities in delivering newer and more effective bio-therapeutic agents for the treatment of CNS disorders. Bio-therapeutics like proteins, peptides, monoclonal antibodies, growth factors, and nucleic acids are thought to have a profound effect on halting the progression of neurodegenerative disorders and also provide a unique function of restoring damaged cells. We provide a review of the nano-sized formulation-based drug delivery systems and alternate modes of delivery, like the intranasal route, to carry bio-therapeutics effectively to the brain.
目前的治疗策略在治疗与中枢神经系统（CNS）相关的疾病方面效率不高，仅能部分缓解症状，而非改善疾病。随着人口结构的变化，中枢神经系统疾病，尤其是神经退行性疾病的发病率预计将大幅上升。当前的治疗方案伴有严重的副作用，特别是考虑到这些大多是慢性疗法且涉及老年人群体。在本综述中，我们强调了在提供更新、更有效的生物治疗药物以治疗中枢神经系统疾病方面所面临的挑战和机遇。蛋白质、肽、单克隆抗体、生长因子和核酸等生物治疗药物被认为对阻止神经退行性疾病的进展具有深远影响，并且还具有修复受损细胞的独特功能。我们综述了基于纳米制剂的药物递送系统以及替代递送方式，如鼻内途径，以有效地将生物治疗药物输送到大脑。
