Radke Robert M, Diller Gerhard-Paul, Baumgartner Helmut
Adult Congenital and Valvular Heart Disease Center, Dept. of Cardiology and Angiology, University Hospital Münster, Münster, Germany.
Expert Rev Cardiovasc Ther. 2013 Jul;11(7):919-31. doi: 10.1586/14779072.2013.811966.
A significant number of adult patients with congenital heart disease suffer from pulmonary arterial hypertension leading to a markedly increased morbidity and mortality. Some defects may be eligible for operative or interventional repair in adulthood but careful selection of candidates is crucial. With the emergence of disease-targeting therapies, symptomatic improvement and stabilization have become possible while the impact on survival currently remains unclear.
相当数量的成年先天性心脏病患者患有肺动脉高压，导致发病率和死亡率显著增加。一些缺陷在成年期可能适合进行手术或介入修复，但仔细挑选合适的患者至关重要。随着针对疾病的治疗方法的出现，症状改善和病情稳定已成为可能，而对生存率的影响目前尚不清楚。
