Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Department of Microbiology, Immunology and Parasitology, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Mycoses. 2014 Feb;57(2):116-20. doi: 10.1111/myc.12111. Epub 2013 Jul 29.
Chromoblastomycosis is a chronic mycosis that affects the skin and subcutaneous tissues caused by several genera of dematiaceous fungi. There is not a treatment of choice. Thus, tools that help guide clinical practice are fundamental. In this sense, antifungal activity tests in vitro could be useful. However, trials with chromoblastomycosis agents are scarce. The aim of this study was to evaluate both the in vitro susceptibility of 60 chromoblastomycosis agents to five antifungals and the combination of amphotericin B (AMB) and terbinafine (TRB). TRB, itraconazole (ITZ) and ketoconazole (KTZ) were, in this order, the drugs which showed better activity against the chromoblastomycosis agents. The less active drugs were voriconazole (VRZ) and AMB. The more differentiated group was Exophiala spinifera. Cladophialophora carrionii and Fonsecaea spp. are significantly more susceptible to KTZ than Phialophora verrucosa, whereas C. carrionii is significantly more sensitive to VRZ than P. verrucosa and E. spinifera. Assays in this direction allow the knowledge of the susceptibility of the causative agents which may help the management of patients with this disease. This study includes the largest number of these agents and of genera found in the literature.
着色芽生菌病是一种慢性真菌病，影响皮肤和皮下组织，由几种暗色真菌引起。目前尚无特效疗法。因此，有助于指导临床实践的工具是至关重要的。在这方面，体外抗真菌活性试验可能是有用的。然而，针对着色芽生菌病药物的试验很少。本研究旨在评估 60 种着色芽生菌病药物对 5 种抗真菌药物的体外敏感性，以及两性霉素 B (AMB)和特比萘芬 (TRB)的联合用药。按顺序，特比萘芬（TRB）、伊曲康唑（ITZ）和酮康唑（KTZ）是对这些着色芽生菌病药物活性最强的药物。活性较差的药物是伏立康唑（VRZ）和 AMB。分化程度更高的组是外瓶霉。卡氏外瓶霉和帚霉属对 KTZ 的敏感性明显高于疣状瓶霉，而卡氏外瓶霉对 VRZ 的敏感性明显高于疣状瓶霉和 spinifera。这种方向的试验可以了解病原体的敏感性，这可能有助于管理患有这种疾病的患者。本研究包括了文献中发现的最大数量的这些药物和属。
