CHU de Bordeaux, Département de Chirurgie Viscérale, F-33000 Bordeaux, France.
Expert Rev Med Devices. 2013 Jul;10(4):501-7. doi: 10.1586/17434440.2013.811834.
Gastrointestinal tissue engineering has emerged over the past 20 years and was often focused on esophagus, stomach or small intestine, whereas bioengineering researches of colorectal tissue are scarce. However, some promising results have been obtained in animal models. Refinements should be performed in scaffold and cell source selection to allow smooth muscle layer regeneration. Indeed, synthetic and natural polymers such as small intestinal submucosa and collagen sponge seeded with organoid units or smooth muscle cells did not allow smooth muscle regeneration. Mesenchymal stem cells derived from adipose tissue seeded on composite scaffold could represent an interesting way to achieve this goal. This article reviews potential indications, current status and perspectives of tissue engineering in the area of colorectal surgery.
胃肠道组织工程在过去 20 年中兴起，研究重点通常集中在食管、胃或小肠，而结直肠组织的生物工程研究则相对较少。然而，在动物模型中已经取得了一些有前景的结果。在支架和细胞源选择方面需要进行改进，以实现平滑肌层的再生。事实上，合成和天然聚合物，如小肠黏膜下层和胶原海绵，接种类器官单位或平滑肌细胞，均不能实现平滑肌的再生。脂肪来源的间充质干细胞接种于复合支架上可能是实现这一目标的一种有前途的方法。本文综述了结直肠外科领域组织工程的潜在适应证、现状和前景。
