Kjar Andrew, McFarland Bailey, Mecham Keetch, Harward Nathan, Huang Yu
Department of Biological Engineering, Utah State University, Logan, UT, 84322, USA.
Bioact Mater. 2020 Sep 8;6(2):460-471. doi: 10.1016/j.bioactmat.2020.08.020. eCollection 2021 Feb.
Bioprinting is a rapidly developing technology for the precise design and manufacture of tissues in various biological systems or organs. Coaxial extrusion bioprinting, an emergent branch, has demonstrated a strong potential to enhance bioprinting's engineering versatility. Coaxial bioprinting assists in the fabrication of complex tissue constructs, by enabling concentric deposition of biomaterials. The fabricated tissue constructs started with simple, tubular vasculature but have been substantially developed to integrate complex cell composition and self-assembly, ECM patterning, controlled release, and multi-material gradient profiles. This review article begins with a brief overview of coaxial printing history, followed by an introduction of crucial engineering components. Afterward, we review the recent progress and untapped potential in each specific organ or biological system, and demonstrate how coaxial bioprinting facilitates the creation of tissue constructs. Ultimately, we conclude that this growing technology will contribute significantly to capabilities in the fields of in vitro modeling, pharmaceutical development, and clinical regenerative medicine.
生物打印是一项迅速发展的技术，用于在各种生物系统或器官中精确设计和制造组织。同轴挤压生物打印作为一个新兴分支，已展现出强大潜力，可增强生物打印的工程通用性。同轴生物打印通过实现生物材料的同心沉积，助力制造复杂的组织构建体。所制造的组织构建体最初是简单的管状脉管系统，但如今已得到大幅发展，能够整合复杂的细胞组成、自组装、细胞外基质图案化、控释以及多材料梯度分布。本文首先简要概述同轴打印的历史，接着介绍关键的工程组件。随后，我们回顾了在每个特定器官或生物系统中的最新进展和未开发潜力，并展示了同轴生物打印如何促进组织构建体的创建。最后，我们得出结论，这项不断发展的技术将对体外建模、药物研发和临床再生医学领域的能力做出重大贡献。
