Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
J Pediatr Surg. 2013 Jul;48(7):1604-8. doi: 10.1016/j.jpedsurg.2013.04.015.
Sacrococcygeal tumors (SCT) are relatively uncommon tumors affecting neonates, infants and children. The aim of this article is to clarify any special characterizations in natural history, clinical presentation and outcome of such tumors treated at South Egypt Cancer Institute, the only research center located in South Egypt.
A retrospective analysis of children with SCT treated at the Pediatric Oncology department South Egypt Cancer Institute, Assiut University between 2004 and 2010.
Nineteen children were included in the study. Age ranged between 10 days and 5 years. All but three had sacral mass at presentation. AFP levels ranged between normal age-related levels and 217,200 ng/ml. Initial resection was possible in 11, while eight patients with clinical suggestion of advanced malignant disease were inoperable. They received initial chemotherapy followed by delayed surgery. Yolk sac tumor (YST) was reported in 52.9% of patients. Recurrence was reported in 5 patients (3 mature teratomas and 2 YST). Five-year OS and RFS rates of patients who had malignant disease were 81.8% and 77.8% respectively.
Older age and delay in presentation that resulted in predominance of extensive disease and malignant transformation at presentation were the main challenges we faced in managing patients with SCT in our locality.
尾骨肿瘤（SCT）是一种相对罕见的影响新生儿、婴儿和儿童的肿瘤。本文旨在阐明在南埃及癌症研究所（位于埃及南部的唯一研究中心）治疗的此类肿瘤的自然病史、临床表现和结果方面的任何特殊特征。
对 2004 年至 2010 年期间在南埃及癌症研究所小儿肿瘤科接受治疗的患有 SCT 的儿童进行回顾性分析。
19 名儿童纳入研究。年龄在 10 天至 5 岁之间。除了 3 人以外，所有人在就诊时都有骶骨肿块。AFP 水平在正常年龄相关水平和 217,200ng/ml 之间。11 名患者可进行初始切除，而 8 名有临床提示恶性疾病的患者无法手术。他们接受了初始化疗，随后进行了延迟手术。52.9%的患者报告为卵黄囊瘤（YST）。5 名患者（3 例成熟畸胎瘤和 2 例 YST）出现复发。患有恶性疾病的患者的 5 年 OS 和 RFS 率分别为 81.8%和 77.8%。
在我们当地管理 SCT 患者时，我们面临的主要挑战是年龄较大和就诊延迟，这导致广泛疾病和恶性转化的发生率较高。
