Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Urology. 2013 Aug;82(2):270-7. doi: 10.1016/j.urology.2013.04.045.
Alpha-blockers and antimuscarinics combination therapy has been commonly used for treatment of male lower urinary tract symptoms (LUTS). We conducted a meta-analysis aimed to access the relative efficacy and safety of combination therapy. We systematically searched Medline, Cochrane, and Embase for eligible studies. Fifteen randomized studies with 4556 patients were included. Overall, combination therapy significantly improved the urgency, voiding frequency, International Prostate Symptom Score (IPSS) total scores, and IPSS storage subscores. Addition of antimuscarinics had little effect on urinary function. The incidences of adverse events were acceptably low. Our meta-analysis demonstrated that the combination therapy was a safe, well-tolerated, and effective treatment for male LUTS.
α-受体阻滞剂和抗胆碱能药物联合治疗已广泛用于男性下尿路症状（LUTS）的治疗。我们进行了一项荟萃分析，旨在评估联合治疗的相对疗效和安全性。我们系统地检索了 Medline、Cochrane 和 Embase 中的合格研究。共纳入了 15 项随机研究，涉及 4556 名患者。总体而言，联合治疗显著改善了尿急、排尿频率、国际前列腺症状评分（IPSS）总分和 IPSS 存储子评分。加用抗胆碱能药物对尿功能影响不大。不良事件的发生率可接受。我们的荟萃分析表明，联合治疗是一种安全、耐受良好且有效的男性 LUTS 治疗方法。
