Deckart H, Deckart E, Behringer F, Kühne H, Adam B, Apitz H, Eifler H, Grambow H, Hannemann R, Hans R
Klinik für Nuklearmedizin und Endokrinologie, Klinikum Berlin-Buch, GDR.
Acta Med Austriaca. 1990;17 Suppl 1:39-41.
The incidence of hyperthyroidism was observed in the area of Berlin (1.2 million inhabitants) and in a rural district in the geographical region of the "Mark Brandenburg" (48.115 inhabitants) during the period from 1975 und 1989. This area is characterized with a iodine deficiency grade II (WHO). In 1985 an iodine salt supplementation was introduced by law. The period before iodine salt supplementation 1975-1985 was compared to the period after iodine prophylaxis: there was an increase in hyperthyroidism in the Berlin-area by the ratio 1:3.1 and 1:2.8 (1975-83 compared to 1988 and 1989), in the rural district by 1:1.7 (1980-1985 compared to 1986/87). The ratio autonomy (non immunogenic form) to immunogenic etiology was 1:12 (1977-83), and changed to 1:1.45 in 1988 and 1:16.3 in 1989 after iodine supplementation. The sex ratio male:female was 1:10 before, and 1:6.8 after prophylaxis for hyperthyroidism in total, in autonomy the ratio was observed as 1:12 before and 1:7.7 (1988), 1:4.7 (1989) after supplementation, in immunogenic hyperthyroidism 1:10 unchanged in the early and late period of observation. The increase of hyperthyroidism after iodine prophylaxis correlated well with the consumption of thyrostatic drug Thiamazol (Methimazol) for the whole country. The defined daily dose (DDD)/1000 inhabitants/day increased during the observation time from 0.5 (1984), 0.55 (1985), 0.66 (1986), to 1.47 (1987), 1.26 (1988) and 0.81 (1989). The results are compared and discussed with reports from USA, Iceland, Great Britain, Denmark, Italy and Tasmania. During the period of seven years (1980-87) in the rural district a seasonal dependence of onset in hyperthyroidism was observed in spring time between May and June only in immunogenic hyperthyroidism, despite in thyroidal autonomy the disease began throughout the year without a seasonal peak.
1975年至1989年期间，在柏林地区（120万居民）和“勃兰登堡边区”地理区域内的一个农村地区（48115名居民）观察了甲状腺功能亢进症的发病率。该地区的特点是碘缺乏程度为二级（世界卫生组织标准）。1985年依法开始补充碘盐。将补充碘盐前的时期（1975 - 1985年）与碘预防后的时期进行比较：柏林地区甲状腺功能亢进症的发病率增加了1:3.1和1:2.8（1975 - 1983年与1988年和1989年相比），农村地区增加了1:1.7（1980 - 1985年与1986/87年相比）。自主性（非免疫原性形式）与免疫原性病因的比例在1977 - 1983年为1:12，在补充碘后，1988年变为1:1.45，1989年变为1:16.3。甲状腺功能亢进症总体上，男性与女性的性别比在预防前为1:10，预防后为1:6.8；在自主性甲状腺功能亢进症中，补充碘前为1:12，补充碘后1988年为1:7.7，1989年为1:4.7；在免疫原性甲状腺功能亢进症中，观察早期和晚期的性别比均为1:10不变。碘预防后甲状腺功能亢进症的增加与全国范围内抗甲状腺药物甲巯咪唑（他巴唑）的消费量密切相关。在观察期间，每1000居民/天的限定日剂量（DDD）从1984年的0.5、1985年的0.55、1986年的0.66增加到1987年的1.47、1988年的1.26和1989年的0.81。将结果与美国、冰岛、英国、丹麦、意大利和塔斯马尼亚的报告进行了比较和讨论。在农村地区的七年期间（1980 - 1987年），仅在免疫原性甲状腺功能亢进症中观察到甲状腺功能亢进症发病的季节性依赖性，发病时间为春季的五月至六月，而在甲状腺自主性疾病中，该病全年发病，无季节性高峰。
