Galvan G
Institut für Nuklearmedizin und Endokrinologie, Landeskrankenanstalten Salzburg.
Acta Med Austriaca. 1993;20(1-2):3-5.
Austria is an iodine deficient area as are most parts of Europe. Goiters were always a natural phenomenon. In 1924 goiter prevalence in school children was 45 to 47% and a first attempt was made with iodized salt. This iodized salt (5 mg NaI/kg salt) was not used widely and goiter prevalence remained unchanged for decades. Therefore, in 1963, salt iodized with 10 mg KI/kg was introduced by law in a semi-mandatory way: Non-iodized salt was allowed to be sold only by special request. Consequently, in 1982, 68% of the total salt sold was iodized salt, goiter prevalence dropped to 1.5% in first graders, hypothyroidism in newborns was 1:4,600 and cretinism disappeared. However, in 18 years old females, goiter prevalence was still 13%, and in adults up to 30%. Investigations in various regions of Austria showed that iodine supplementation was insufficient with a mean urinary excretion of 42 to 75 micrograms I/g Cr. Therefore the Austrian Society of Nuclear Medicine (ONG) demanded the raise of the iodine content of salt to 20 mg KI/kg. Finally, in 1990 a new law was issued by the Government following this proposal. In 1992, investigations were done in various regions of Austria demonstrating a normalized iodine excretion of 129 to 177 micrograms I/g Cr. Further prospective and retrospective studies will be done by the ONG.
奥地利是缺碘地区,欧洲大部分地区也是如此。甲状腺肿一直是一种自然现象。1924年,学龄儿童的甲状腺肿患病率为45%至47%,人们首次尝试使用加碘盐。这种加碘盐(5毫克碘化钠/千克盐)并未得到广泛使用,甲状腺肿患病率几十年来一直没有变化。因此,1963年,法律以半强制方式引入了含10毫克碘化钾/千克的加碘盐:非加碘盐只有在特殊要求下才允许销售。结果,1982年,销售的盐总量中有68%是加碘盐,一年级学生的甲状腺肿患病率降至1.5%,新生儿甲状腺功能减退症的发病率为1:4600,克汀病消失。然而,18岁女性的甲状腺肿患病率仍为13%,成年人中这一比例高达30%。奥地利不同地区的调查显示,碘补充不足,尿碘平均排泄量为42至75微克碘/克肌酐。因此,奥地利核医学协会(ONG)要求将盐中的碘含量提高到20毫克碘化钾/千克。最终,1990年政府根据这一建议颁布了一项新法律。1992年,在奥地利不同地区进行了调查,结果显示碘排泄量正常化,为129至177微克碘/克肌酐。ONG将进一步开展前瞻性和回顾性研究。