每日一次静脉注射妥布霉素在住院治疗急性肺部感染的成年囊性纤维化患者中的药代动力学和药效学研究。
Pharmacokinetics and pharmacodynamics of once-daily administration of intravenous tobramycin in adult patients with cystic fibrosis hospitalized for an acute pulmonary exacerbation.
机构信息
Albany College of Pharmacy and Health Sciences, Albany, New York, USA.
出版信息
Antimicrob Agents Chemother. 2013 Oct;57(10):5175-7. doi: 10.1128/AAC.00539-13. Epub 2013 Jul 29.
Abstract
The serum pharmacokinetic profile of intravenous (i.v.) tobramycin administration was characterized for a sample of nine adult patients with cystic fibrosis (CF) who were hospitalized for an acute pulmonary exacerbation. Current recommended i.v. tobramycin dosing protocols are predicted through modeling and simulation to be suboptimal. Empirical tobramycin regimens of ≥15 mg/kg of body weight administered i.v. once daily should be evaluated for adult patients with CF to optimize outcomes.
摘要
静脉注射（i.v.）妥布霉素给药的血清药代动力学特征在 9 名患有囊性纤维化（CF）的成年住院患者中进行了研究，这些患者因急性肺部恶化而住院。目前推荐的 i.v. 妥布霉素给药方案通过建模和模拟预测是不理想的。应评估体重 ≥15mg/kg 的经验性 i.v. 妥布霉素每日一次给药方案在 CF 成年患者中的疗效，以优化治疗结果。
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