Wendelboe Nielsen O, Hansen S, Christensen P, Grønlund J
Department of Research & Development, AMIS A/S, Odense, Denmark.
Acta Anaesthesiol Scand. 1990 Jul;34(5):354-7. doi: 10.1111/j.1399-6576.1990.tb03102.x.
The acetylene rebreathing method is a reliable noninvasive method for estimation of cardiac output. However, the method is not commonly used for clinical purposes. This is due mainly to the fact that acetylene is explosive at concentrations above 2% and that acetylene at concentrations above 0.5% has an unpleasant taste. In the present study we have investigated whether it is possible to reduce the concentration of acetylene to 0.3% in the rebreathing bag without degrading the repeatability of the estimated cardiac output. The problem was elucidated theoretically and experimentally. A theoretical investigation was carried out by producing an acetylene rebreathing curve from a single alveolus lung model. The theoretical study showed that the random noise arising from the gas analyzer gives rise to less than 10% of the total variation of the estimated cardiac output. The results of the experimental study showed that it is possible to reduce the acetylene concentration to 0.3% without decreasing the reproducibility of the acetylene rebreathing method.
乙炔重呼吸法是一种可靠的无创心输出量估算方法。然而，该方法并不常用于临床。这主要是因为乙炔在浓度高于2%时具有爆炸性，且浓度高于0.5%时会有难闻的味道。在本研究中，我们调查了是否有可能在不降低心输出量估算重复性的情况下，将重呼吸袋中的乙炔浓度降低至0.3%。从理论和实验上阐明了该问题。通过单个肺泡肺模型生成乙炔重呼吸曲线进行了理论研究。理论研究表明，气体分析仪产生的随机噪声导致估算心输出量总变化的比例小于10%。实验研究结果表明，有可能将乙炔浓度降低至0.3%而不降低乙炔重呼吸法的可重复性。
