Pinto F, Ragazzoni A, Amantini A, de Scisciolo G, Bartelli M, Rossi R, Pieraccioli E
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Acta Anaesthesiol Scand. 1990 Jul;34(5):389-92. doi: 10.1111/j.1399-6576.1990.tb03108.x.
The effects on median nerve somatosensory evoked potentials (SEPs) of analgesic doses of fentanyl, meperidine or morphine and of sodium thiopental (STP) anesthesia (4 mg/kg) were tested in 36 surgical patients. We also explored changes in SEP components as a function of their scalp location. Before and after medication, responses were recorded from the scalp overlying the parietal cortex (ipsi- and contralateral to the stimulated arm) and the precentral (contralateral) cortex. None of the three opiates affected SEP latencies or amplitudes. The barbiturate increased the amplitudes of subcortical and early cortical components (N18, N20, P22, P25), whose latencies, however, were not significantly modified. The effect of STP on later SEP cortical components depended on their scalp topography: parietal N33 and P45 underwent significant changes in both latency and amplitude, whereas precentral N30 showed a significant amplitude increase only. Thiopental anesthesia produces clearer short-latency SEP recordings, from both parietal (components N20-P25) and precentral (P22, N30) areas.
在36例外科手术患者中，测试了镇痛剂量的芬太尼、哌替啶或吗啡以及硫喷妥钠（STP）麻醉（4mg/kg）对正中神经体感诱发电位（SEP）的影响。我们还探讨了SEP各成分随头皮位置变化的情况。用药前后，在顶叶皮质（受刺激手臂的同侧和对侧）及中央前回（对侧）皮质上方的头皮记录反应。三种阿片类药物均未影响SEP的潜伏期或波幅。巴比妥酸盐增加了皮质下和早期皮质成分（N18、N20、P22、P25）的波幅，但其潜伏期未发生显著改变。STP对SEP后期皮质成分的影响取决于其头皮位置：顶叶的N33和P45潜伏期和波幅均发生显著变化，而中央前回的N30仅波幅显著增加。硫喷妥钠麻醉能使顶叶（成分N20 - P25）和中央前回（P22、N30）区域记录到更清晰的短潜伏期SEP。
