Russ W, Kling D, Schwandt H J, Krumholz W, Hempelmann G
Department of Anaesthesiology, Justus Liebig-University of Giessen, FRG.
Neurol Res. 1989 Mar;11(1):51-6. doi: 10.1080/01616412.1989.11739862.
Somatosensory evoked potentials (SEP) after median nerve stimulation were recorded in 40 patients during infusion of either 15 mg/kg bw thiopentone or 1 mg/kg bw etomidate (n = 10) within 15 min and after 0.3 mg/kg bw etomidate (n = 20). Marked alterations of SEP waveforms and changes in latencies were observed in all patients. Central conduction time (CCT) was significantly correlated to plasma thiopentone concentration. Infusion of high doses of thiopentone and etomidate was followed by a complete loss of middle and long latency components. Amplitude of the primary cortical SEP N20 was found to be unchanged after thiopentone and to be increased after etomidate, indicating the synchronizing properties of this drug. A pronounced increase in SEP latencies and CCT and waveform alterations have to be considered during hypnotic drug administration in intensive care medicine and intraoperatively.
在40例患者输注15mg/kg体重硫喷妥钠或1mg/kg体重依托咪酯（n = 10）后15分钟内以及输注0.3mg/kg体重依托咪酯（n = 20）后，记录正中神经刺激后的体感诱发电位（SEP）。所有患者均观察到SEP波形的明显改变和潜伏期变化。中枢传导时间（CCT）与血浆硫喷妥钠浓度显著相关。输注高剂量硫喷妥钠和依托咪酯后，中、长潜伏期成分完全消失。发现硫喷妥钠后初级皮质SEP N20的波幅未改变，依托咪酯后波幅增加，表明该药物具有同步特性。在重症监护医学和手术中使用催眠药物时，必须考虑SEP潜伏期和CCT的显著增加以及波形改变。
