Nydahl P A, Axelsson K, Larsson P G, Philipson L, Leissner P, Sjöstrand U H
Department of Anesthesia, Orebro Medical Centre Hospital, Sweden.
Acta Anaesthesiol Scand. 1990 Jul;34(5):393-6. doi: 10.1111/j.1399-6576.1990.tb03109.x.
This study was undertaken to assess the effects of intravenous administration of mepivacaine and etidocaine on muscle function. Seven male volunteers were given mepivacaine (5 mg/kg) and etidocaine (50 mg) intravenously, on separate occasions. A reference group of 11 male volunteers received 0.9% saline solution intravenously. Muscle function was tested by measurements of isometric muscle force of knee extension and by quantitative electromyographic (EMG) recordings from the quadriceps muscle during knee extension at different degrees of isometric muscle force. At the end of the mepivacaine and etidocaine infusions, the mean venous plasma concentrations of the two anaesthetic agents were 2.9 and 1.2 micrograms/ml, respectively. The muscle strength remained unchanged during infusion of the two local anaesthetics. Mepivacaine had a minor effect on the mean rectified EMG amplitudes at the end of the infusion at maximal voluntary muscle contraction, but no such effect was observed at submaximal knee extension force. However, at the plasma concentrations mentioned above, the clinical influence of intravenous infusion of the local anaesthetics on muscle function was negligible.
本研究旨在评估静脉注射甲哌卡因和依替卡因对肌肉功能的影响。7名男性志愿者在不同时间分别静脉注射甲哌卡因（5mg/kg）和依替卡因（50mg）。11名男性志愿者组成的参照组静脉注射0.9%的盐溶液。通过测量膝关节伸展的等长肌力以及在不同等长肌力程度的膝关节伸展过程中对股四头肌进行定量肌电图（EMG）记录来测试肌肉功能。在甲哌卡因和依替卡因输注结束时，两种麻醉剂的平均静脉血浆浓度分别为2.9和1.2微克/毫升。在输注两种局部麻醉剂期间，肌肉力量保持不变。在最大自主肌肉收缩时，甲哌卡因在输注结束时对平均整流EMG振幅有轻微影响，但在次最大膝关节伸展力时未观察到这种影响。然而，在上述血浆浓度下，静脉输注局部麻醉剂对肌肉功能的临床影响可忽略不计。
