Medical Oncology Department, Hospital Infanta Sofia, Madrid, Spain.
Clin Transl Oncol. 2013 Dec;15(12):996-1003. doi: 10.1007/s12094-013-1082-5. Epub 2013 Jul 30.
Colorectal cancer (CRC) is the most common malignant tumor in Western countries. Despite efforts made to implement screening programmes for early detection and treatment, still half of the patients present or will eventually develop distant metastasis. Management of advanced CRC should be discussed within an experienced multidisciplinary team, to adequately select the most appropriate systemic therapeutic option, as well as the optimal way to integrate it with surgical procedures when indicated. Disease localization and extent, resectability of primary and metastatic disease, tumor biology and dynamics, clinical symptoms, personal preferences and patient's ability to tolerate intensive chemotherapy or extensive surgical procedures are the key factors to properly design a customized treatment plan. The aim of the current manuscript is to provide synthetic practical guidelines regarding therapeutic options for advanced CRC.
结直肠癌（CRC）是西方国家最常见的恶性肿瘤。尽管为早期发现和治疗实施了筛查计划，但仍有一半的患者出现或最终会发生远处转移。在经验丰富的多学科团队中讨论晚期 CRC 的管理，以充分选择最合适的系统治疗方案，以及在有指征时最佳地将其与手术结合的方式。疾病定位和范围、原发和转移疾病的可切除性、肿瘤生物学和动力学、临床症状、个人偏好以及患者耐受强化化疗或广泛手术的能力是正确设计定制治疗计划的关键因素。本文的目的是提供有关晚期 CRC 治疗选择的综合实用指南。
