Oncology Department, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain.
Clin Transl Oncol. 2010 Nov;12(11):729-34. doi: 10.1007/s12094-010-0587-4.
Colorectal cancer is the first cause of cancer diagnosis in Spain. Over half of the patients are diagnosed with or will eventually develop distant metastasis. The current manuscript aims to provide synthetic practical guidelines for the therapeutic approaches in advanced disease. Available systemic therapeutic options, and integration and sequencing of chemotherapy with surgical procedures are discussed. Extent of disease, treatment objective, tumor kras mutation status, as well as patient's functional and comorbid conditions shall be considered to properly design the most adequate therapeutic strategy.
结直肠癌是西班牙癌症诊断的首要原因。超过一半的患者被诊断出患有或最终将发展为远处转移。本文旨在为晚期疾病的治疗方法提供综合实用的指南。讨论了可用的系统治疗选择，以及化疗与手术的整合和序贯。应考虑疾病的范围、治疗目标、肿瘤 kras 突变状态以及患者的功能和合并症状况，以合理设计最合适的治疗策略。
