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Directing transcription to the right way.引导转录到正确的方向。
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Promoter directionality is controlled by U1 snRNP and polyadenylation signals.启动子方向由 U1 snRNP 和多聚腺苷酸化信号控制。
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Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP.转录暂停位点划定由 U1 snRNP 稳定抑制的核小体相关的早期聚腺苷酸化。
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The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs.U1 反义核酸锁核酸（AMO）破坏 U1 snRNP 结构，促进前体 mRNA 的内含子 PCPA 修饰。
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How bidirectional becomes unidirectional.双向如何变成单向。
Nat Struct Mol Biol. 2013 Sep;20(9):1022-4. doi: 10.1038/nsmb.2657.
6
RNA exosome depletion reveals transcription upstream of active human promoters.RNA外切体缺失揭示了活跃人类启动子上游的转录过程。
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A potential mechanism underlying U1 snRNP inhibition of the cleavage step of mRNA 3' processing.U1 snRNP 抑制 mRNA 3' 加工切割步骤的潜在机制。
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Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters.新生RNA测序揭示了人类启动子处广泛的暂停和分歧起始。
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FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.FUS 通过介导 RNA 聚合酶 II（RNAP II）与 U1 小核核糖核蛋白（U1 snRNP）之间的相互作用，在转录与剪接的偶联过程中发挥作用。
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Position-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNP.U1小核核糖核蛋白对前体信使核糖核酸3'末端加工切割步骤的位置依赖性抑制作用
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Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability.酵母 Sirtuin 家族成员维持转录稳态以确保基因组稳定性。
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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF.胚胎干细胞中esBAF对广泛非编码转录的抑制作用。
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3
TRAP150 activates splicing in composite terminal exons.TRAP150激活复合末端外显子中的剪接。
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本文引用的文献
1
Promoter directionality is controlled by U1 snRNP and polyadenylation signals.启动子方向由 U1 snRNP 和多聚腺苷酸化信号控制。
Nature. 2013 Jul 18;499(7458):360-3. doi: 10.1038/nature12349. Epub 2013 Jun 23.
2
Gene loops enhance transcriptional directionality.基因环增强转录方向。
Science. 2012 Nov 2;338(6107):671-5. doi: 10.1126/science.1224350. Epub 2012 Sep 27.
3
PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters.启动子上游转录本与 mRNA 具有相似的特征，并且存在于所有三种主要类型的哺乳动物启动子的上游。
Nucleic Acids Res. 2011 Sep 1;39(16):7179-93. doi: 10.1093/nar/gkr370. Epub 2011 May 19.
4
Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation.RNA 聚合酶 II 的暂停会破坏 DNA 特异性核小体的组织，从而实现精确的基因调控。
Cell. 2010 Nov 12;143(4):540-51. doi: 10.1016/j.cell.2010.10.004.
5
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation.U1 snRNP 保护前体 mRNA 免受过早切割和多聚腺苷酸化。
Nature. 2010 Dec 2;468(7324):664-8. doi: 10.1038/nature09479. Epub 2010 Sep 29.
6
Divergent transcription: a new feature of active promoters.发散转录：活跃启动子的一个新特征。
Cell Cycle. 2009 Aug 15;8(16):2557-64. doi: 10.4161/cc.8.16.9305. Epub 2009 Aug 19.
7
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters.新生RNA测序揭示了人类启动子处广泛的暂停和分歧起始。
Science. 2008 Dec 19;322(5909):1845-8. doi: 10.1126/science.1162228. Epub 2008 Dec 4.
8
Divergent transcription from active promoters.来自活性启动子的分歧转录
Science. 2008 Dec 19;322(5909):1849-51. doi: 10.1126/science.1162253. Epub 2008 Dec 4.
9
RNA exosome depletion reveals transcription upstream of active human promoters.RNA外切体缺失揭示了活跃人类启动子上游的转录过程。
Science. 2008 Dec 19;322(5909):1851-4. doi: 10.1126/science.1164096. Epub 2008 Dec 4.
10
DNA topology and a minimal set of basal factors for transcription by RNA polymerase II.DNA拓扑结构与RNA聚合酶II转录所需的一组最小基本因子
Cell. 1993 May 7;73(3):533-40. doi: 10.1016/0092-8674(93)90140-l.
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