Antoniuk Sérgio A
Universidade Federal do Parana, 80035-010 Curitiba, Brasil.
Rev Neurol. 2013 Sep 6;57 Suppl 1:S149-54.
Acute muscle weakness, a common disorder in pediatrics, can occur from impairment of any part of the motor unit, including the upper motor neuron, lower motor neuron, peripheral nerve, neuromuscular junction or muscle. It usually manifests itself as an acute or hyperacute motor disorder of progressive or rapidly progressive course. Acute muscle weakness is a neuromuscular emergency, especially if it affects the respiratory or oropharyngeal musculature. The location of the motor weakness and associated neurological signs and symptoms usually indicate the location of the lesion. The onset, speed and clinical evolution, as well as other data from the patient's history, suggest the pathophysiological differential diagnosis. Successful treatment depends on the immediate and correct differential diagnosis. This paper presents the main differential diagnosis of main neuromuscular diseases that cause acute muscle weakness in children.
急性肌无力是儿科常见疾病，运动单位的任何部分受损都可能引发，包括上运动神经元、下运动神经元、周围神经、神经肌肉接头或肌肉。它通常表现为急性或超急性运动障碍，病程呈进行性或快速进行性。急性肌无力是一种神经肌肉急症，尤其是当它影响呼吸或口咽肌肉组织时。运动无力的部位以及相关的神经体征和症状通常提示病变部位。发病情况、进展速度和临床演变，以及患者病史中的其他资料，有助于进行病理生理鉴别诊断。成功的治疗取决于及时且正确的鉴别诊断。本文介绍了导致儿童急性肌无力的主要神经肌肉疾病的主要鉴别诊断。
