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经皮血栓切除术、带膜支架置入术和高压血管成形术治疗动静脉血液透析移植物血栓形成伴静脉吻合口狭窄

Treatment of arteriovenous haemodialysis graft thrombosis associated to venous anastomotic stenosis by surgical thrombectomy, covered stenting and high-pressure angioplasty.

机构信息

Servicio de Angiología y Cirugía Vascular, Hospital del Mar, Barcelona, Spain.

出版信息

Nefrologia. 2013;33(4):564-70. doi: 10.3265/Nefrologia.pre2012.Nov.11756.

DOI:10.3265/Nefrologia.pre2012.Nov.11756
PMID:23897189
Abstract

INTRODUCTION/OBJECTIVE: The NKF-K/DOQI guidelines recommend that the repermeabilisation of thrombosed arteriovenous (AV) grafts for haemodialysis must achieve positive results in 40% at 3 months, if it is performed by endovascular technique, or 50% at 6 months and 40% at one year if it is performed by surgical procedure. This study assesses the results of a hybrid treatment (minimally invasive surgical and endovascular treatment) of AV graft thrombosis associated to venous anastomotic stenosis.

PATIENTS AND METHOD

Between 2008 and 2012, 27 consecutive patients underwent surgery (average age: 69.7, 52% male) due to AV graft thrombosis associated to venous anastomotic stenosis (74.1% upper extremity) by open thrombectomy (mini-incision in the graft), covered self-expanding stent (Fluency, Bard), and high pressure angioplasty (>20atm).

RESULTS

Immediate patency with effective haemodialysis was 89%, with an average stay of 1.9 days and no postoperative complications. Primary patency at 3, 6, and 12 months was 51.9%, 44.4%, and 16.2% respectively (mean follow-up: 15 months). Secondary patency after a new thrombotic episode and similar procedure (62.9% of cases) was 70.4%, 51.9%, and 37% respectively.

CONCLUSIONS

Despite being safe and minimally invasive, this hybrid treatment for AV graft thrombosis associated to venous anastomotic stenosis only achieves competitive results compared to open surgery after a second iterative procedure. Because of this and the associated costs, this technique should be reserved for difficult surgical approach stenoses.

摘要

简介/目的:NKF-K/DOQI 指南建议,对于血栓形成的动静脉(AV)移植物,若采用血管内技术,则必须在 3 个月时达到 40%的再通率,若采用手术治疗,则必须在 6 个月时达到 50%,在 1 年时达到 40%,才能获得阳性结果。本研究评估了微创外科与血管内治疗联合治疗伴静脉吻合口狭窄的 AV 移植物血栓形成的效果。

患者与方法

2008 年至 2012 年,27 例连续患者因伴静脉吻合口狭窄的 AV 移植物血栓形成而行手术治疗(平均年龄:69.7 岁,52%为男性),采用开放血栓切除术(在移植物上做小切口)、带膜自膨式支架(Fluency,Bard)和高压血管成形术(>20atm)。

结果

即时通畅率为 89%,可有效进行血液透析,平均住院时间为 1.9 天,无术后并发症。3、6 和 12 个月时的一期通畅率分别为 51.9%、44.4%和 16.2%(平均随访时间:15 个月)。再次发生血栓形成和类似手术(62.9%的病例)后的二次通畅率分别为 70.4%、51.9%和 37%。

结论

尽管这种治疗伴静脉吻合口狭窄的 AV 移植物血栓形成的混合疗法安全且微创,但在进行第二次迭代手术后,与开放手术相比,仅能获得竞争性结果。由于这一点及其相关费用,该技术应保留用于治疗困难的手术入路狭窄。

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