Division of Gastroenterology, Department of Medicine, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889-5600, USA.
Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):510-1. doi: 10.1038/nrgastro.2013.138. Epub 2013 Jul 30.
With expanding waistlines, the prevalence of NAFLD has burgeoned to become the leading cause of chronic liver disease in the USA. A subset of patients with NAFLD meet criteria for NASH with its inherent risk of progression to cirrhosis. Verma et al. addressed the utility of alanine aminotransferase levels for predicting NASH or advanced fibrosis to decide who would benefit from the definitive test of liver biopsy.
随着腰围的不断增大，非酒精性脂肪性肝病（NAFLD）的发病率也迅速增加，成为美国慢性肝病的主要原因。NAFLD 患者中有一部分符合非酒精性脂肪性肝炎（NASH）的标准，其存在进展为肝硬化的固有风险。Verma 等人探讨了丙氨酸氨基转移酶（ALT）水平在预测 NASH 或肝纤维化进展方面的作用，以确定哪些患者需要进行肝活检这一明确的诊断性检查。
